Intragenic anaplastic lymphoma kinase (ALK) rearrangements: translocations as a novel mechanism of ALK activation in neuroblastoma tumors. (Q38953705)

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19 February 2020

title

Intragenic anaplastic lymphoma kinase (ALK) rearrangements: translocations as a novel mechanism of ALK activation in neuroblastoma tumors (English)

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19 February 2020

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1

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19 February 2020

Jonas Abrahamsson

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19 February 2020

Per Kogner

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19 February 2020

Tommy Martinsson

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19 February 2020

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Bengt Hallberg

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19 February 2020

8

Ruth H Palmer

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19 February 2020

3

Kristina Ruuth

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19 February 2020

2

Magnus Hansson

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19 February 2020

author name string

Anna Djos

4

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19 February 2020

Ana Berbegall

5

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19 February 2020

Niloufar Javanmardi

6

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19 February 2020

Rosa Noguera

9

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19 February 2020

publication date

23 September 2014

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Genes, Chromosomes and Cancer

19 February 2020

published in

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19 February 2020

volume

54

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19 February 2020

issue

2

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19 February 2020

page(s)

99-109

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Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor.

19 February 2020

cites work

1 reference

Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment.

21 January 2018

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High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset

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Characterization of rearrangements involving the ALK gene reveals a novel truncated form associated with tumor aggressiveness in neuroblastoma

21 January 2018

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Oncogenic mutations of ALK kinase in neuroblastoma

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Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification

21 January 2018

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High anaplastic lymphoma kinase immunohistochemical staining in neuroblastoma and ganglioneuroblastoma is an independent predictor of poor outcome

21 January 2018

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Activating mutations in ALK provide a therapeutic target in neuroblastoma

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ALK and NSCLC: Targeted therapy with ALK inhibitors

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Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology

21 January 2018

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Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

21 January 2018

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Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

21 January 2018

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Overall genomic pattern is a predictor of outcome in neuroblastoma

21 January 2018

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2p24 Gain region harboring MYCN gene compared with MYCN amplified and nonamplified neuroblastoma: biological and clinical characteristics

21 January 2018

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Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

21 January 2018

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Recent advances in neuroblastoma

21 January 2018

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Appearance of the novel activating F1174S ALK mutation in neuroblastoma correlates with aggressive tumor progression and unresponsiveness to therapy

21 January 2018

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Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

21 January 2018

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Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin.

21 January 2018

1 reference

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

21 January 2018

1 reference

Identification of ALK as a major familial neuroblastoma predisposition gene

21 January 2018

1 reference

Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma.

21 January 2018

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Integrative genomics viewer

21 January 2018

1 reference

Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells.

21 January 2018

1 reference

Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study).

21 January 2018

1 reference

High incidence of DNA mutations and gene amplifications of theALKgene in advanced sporadic neuroblastoma tumours

21 January 2018

1 reference

7 January 2021

Transcription as a source of genome instability

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7 January 2021

Accumulation of Segmental Alterations Determines Progression in Neuroblastoma

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7 January 2021

The genetic and clinical significance of MYCN gain as detected by FISH in neuroblastoma

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7 January 2021

Evolution of unbalanced gain of distal chromosome 2p in neuroblastoma

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7 January 2021