Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by Diketo acid derivatives (Q38968700)

8 September 2017

Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by Diketo acid derivatives (English)

1 reference

8 September 2017

12

1 reference

Francesco Saverio Di Leva

8 September 2017

Francesco Saverio Di Leva

2

0 references

Francesca Esposito

Francesca Esposito

8

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Roberta Costi

Roberta Costi

10

0 references

Sandro Cosconati

Sandro Cosconati

11

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Angela Corona

Angela Corona

1

0 references

Enzo Tramontano

Enzo Tramontano

14

0 references

Roberto Di Santo

Roberto Di Santo

13

0 references

Luca Pescatori

4

Luca Pescatori

1 reference

Giuliana Cuzzucoli Crucitti

8 September 2017

5

Giuliana Cuzzucoli Crucitti

1 reference

8 September 2017

7

Olivier Delelis

1 reference

8 September 2017

9

Giuseppe Rigogliuso

1 reference

8 September 2017

Sylvain Thierry

3

1 reference

8 September 2017

Frederic Subra

6

1 reference

8 September 2017

language of work or name

English

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publication date

4 August 2014

1 reference

Antimicrobial Agents and Chemotherapy

8 September 2017

1 reference

8 September 2017

58

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8 September 2017

10

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8 September 2017

6101-6110

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describes a project that uses

8 September 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4187941/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Inhibition of foamy virus reverse transcriptase by human immunodeficiency virus type 1 RNase H inhibitors

9 September 2017

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Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase

9 September 2017

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Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase

9 September 2017

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Past and future. Current drugs targeting HIV-1 integrase and reverse transcriptase-associated ribonuclease H activity: single and dual active site inhibitors

9 September 2017

1 reference

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6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach

9 September 2017

1 reference

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Quantitative analysis of the time-course of viral DNA forms during the HIV-1 life cycle

9 September 2017

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Hypericum hircinum L. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities.

9 September 2017

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Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.

9 September 2017

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Molecular aspects of the RT/drug interactions. Perspective of dual inhibitors

9 September 2017

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Antiviral drug resistance and the need for development of new HIV-1 reverse transcriptase inhibitors

9 September 2017

1 reference

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HIV-1 antiretroviral resistance: scientific principles and clinical applications

9 September 2017

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HIV-1 antiretroviral drug therapy

9 September 2017

1 reference

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Mutagenesis of human immunodeficiency virus reverse transcriptase p51 subunit defines residues contributing to vinylogous urea inhibition of ribonuclease H activity

9 September 2017

1 reference

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Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

9 September 2017

1 reference

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Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors

9 September 2017

1 reference

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Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect

9 September 2017

1 reference

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Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases

9 September 2017

1 reference

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HIV-1 RT-associated RNase H function inhibitors: Recent advances in drug development

9 September 2017

1 reference

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Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.

9 September 2017

1 reference

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Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors

9 September 2017

1 reference

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Antiretroviral therapy in the clinic

9 September 2017

1 reference

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Computational analysis of Human Immunodeficiency Virus (HIV) Type-1 reverse transcriptase crystallographic models based on significant conserved residues found in Highly Active Antiretroviral Therapy (HAART)-treated patients

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187941

Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo

9 September 2017

1 reference

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RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information

9 September 2017

1 reference

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Efficient and specific internal cleavage of a retroviral palindromic DNA sequence by tetrameric HIV-1 integrase

9 September 2017

1 reference

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HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site

9 September 2017

1 reference

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HIV-1 RNase H: recent progress in an exciting, yet little explored, drug target.

9 September 2017

1 reference

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Recent progress in the design of small molecule inhibitors of HIV RNase H.

9 September 2017

1 reference

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Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187941

Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: balance between RNase H activity and nucleotide excision

9 September 2017

1 reference

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Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187941

Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187941

4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187941

Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187941

Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187941

Small molecule inhibitors of HIV RT Ribonuclease H.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187941

Derivatives of 5-nitro-furan-2-carboxylic acid carbamoylmethyl ester inhibit RNase H activity associated with HIV-1 reverse transcriptase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187941

Viral complementation allows HIV-1 replication without integration

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187941

HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187941

Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187941

6-[1-(4-Fluorophenyl)methyl-1H-pyrrol-2-yl)]-2,4-dioxo-5-hexenoic acid ethyl ester a novel diketo acid derivative which selectively inhibits the HIV-1 viral replication in cell culture and the ribonuclease H activity in vitro

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187941

Proteolytic processing of an HIV-1 pol polyprotein precursor: insights into the mechanism of reverse transcriptase p66/p51 heterodimer formation

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187941

Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4187941

21 August 2018

Identifiers

DOI

10.1128/AAC.03605-14

1 reference

8 September 2017

1 reference

8 September 2017

1 reference