Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity. (Q38970938)

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English	Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.	scientific article

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10 March 2020

Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity (English)

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10 March 2020

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based on heuristic

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amiodarone

15 June 2024

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10 March 2020

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Yun-Ping Lim

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10 March 2020

Ching-Hao Cheng

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10 March 2020

Wei-Cheng Chen

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10 March 2020

Shih-Yu Chang

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10 March 2020

Dong-Zong Hung

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10 March 2020

Jih-Jung Chen

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10 March 2020

Lei Wan

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10 March 2020

Wei-Chih Ma

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10 March 2020

Yu-Hsien Lin

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10 March 2020

Cing-Yu Chen

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10 March 2020

Miki Nakajima

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10 March 2020

Chao-Jung Chen

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10 March 2020

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29 July 2014

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10 March 2020

Archives of Toxicology

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10 March 2020

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10 March 2020

1

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10 March 2020

Endogenous gene and protein expression of drug-transporting proteins in cell lines routinely used in drug discovery programs

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Plasma glutathione S-transferase measurements after paracetamol overdose: evidence for early hepatocellular damage

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The disposition of allyl isothiocyanate in the rat and mouse.

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Overcoming drug resistance by regulating nuclear receptors

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A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.

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Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptor

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Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity

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Pregnane X receptor as a target for treatment of inflammatory bowel disorders

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Induction of drug-metabolizing enzymes: a path to the discovery of multiple cytochromes P450

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N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

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Targeting xenobiotic receptors PXR and CAR for metabolic diseases

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Cytochrome p450 and chemical toxicology

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The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

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Enhanced acetaminophen toxicity by activation of the pregnane X receptor

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Identification and quantitation of novel metabolites of amiodarone in plasma of treated patients

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A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor

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Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR).

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Acetaminophen-induced hepatotoxicity

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Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

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The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

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Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells

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10 March 2020

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