Hyperoxia reverses glucotoxicity-induced inhibition of insulin secretion in rat INS-1 β cells (Q38974430)

8 September 2017

Hyperoxia reverses glucotoxicity-induced inhibition of insulin secretion in rat INS-1 β cells (English)

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8 September 2017

Takashi Kondoh

8

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author name string

Tetsuro Matsunaga

1

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8 September 2017

Shiho Li

2

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8 September 2017

Tetsuya Adachi

3

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8 September 2017

Erina Joo

4

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8 September 2017

Ning Gu

5

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8 September 2017

Hanae Yamazaki

6

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8 September 2017

Koichiro Yasuda

7

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8 September 2017

Kinsuke Tsuda

9

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8 September 2017

28 May 2014

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Bioscience, Biotechnology, and Biochemistry

8 September 2017

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8 September 2017

78

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8 September 2017

843-850

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8 September 2017

5

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The molecular mechanisms of pancreatic β-cell glucotoxicity: recent findings and future research directions

8 September 2017

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https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Involvement of chronic stresses in rat islet and INS-1 cell glucotoxicity induced by intermittent high glucose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Glucotoxicity in the INS-1 rat insulinoma cell line is mediated by the orphan nuclear receptor small heterodimer partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Glucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Cellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Increased oxygen consumption rates in response to high glucose detected by a novel oxygen biosensor system in non-human primate and human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Oxygen sensing by HIF hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Intolerant of glucose and gasping for oxygen

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

A role for von Hippel-Lindau protein in pancreatic beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Hyperbaric oxygen exposure improves blood glucose level and muscle oxidative capacity in rats with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Hypoxia-inducible factor-1 alpha is regulated at the post-mRNA level

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Cytokines induce HIF-1 DNA binding and the expression of HIF-1-dependent genes in cultured rat enterocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Cytokines and the regulation of hypoxia-inducible factor (HIF)-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

The hypoxia response pathway and β-cell function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Correlating hypoxia with insulin secretion using a fluorescent hypoxia detection system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Sustained exposure to high glucose concentrations modifies glucose signaling and the mechanics of secretory vesicle fusion in primary rat pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

ß-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Reactive oxygen species and uncoupling protein 2 in pancreatic β-cell function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Reactive oxygen species as a signal in glucose-stimulated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Hypoxia increases leptin expression in human PAZ6 adipose cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

Glucose Down-regulates the Expression of the Peroxisome Proliferator-activated Receptor-α Gene in the Pancreatic β-Cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09168451.2014.905175

10.1080/09168451.2014.905175

21 January 2018

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DOI

1 reference

8 September 2017

1 reference