Tyrosine phosphatase SHP2 increases cell motility in triple-negative breast cancer through the activation of SRC-family kinases. (Q38984571)

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20 March 2020

title

Tyrosine phosphatase SHP2 increases cell motility in triple-negative breast cancer through the activation of SRC-family kinases (English)

1 reference

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triple-negative breast cancer

20 March 2020

main subject

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5

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20 March 2020

author name string

N Sausgruber

1

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20 March 2020

M-M Coissieux

2

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20 March 2020

A Britschgi

3

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20 March 2020

J Wyckoff

4

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20 March 2020

C Leroy

6

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20 March 2020

M B Stadler

7

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20 March 2020

H Voshol

8

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20 March 2020

D Bonenfant

9

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20 March 2020

M Bentires-Alj

10

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20 March 2020

language of work or name

English

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publication date

16 June 2014

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20 March 2020

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20 March 2020

volume

34

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issue

17

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page(s)

2272-2278

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https://scigraph.springernature.com/pub.10.1038/onc.2014.170

20 March 2020

exact match

0 references

cites work

Molecular stratification of triple-negative breast cancers

1 reference

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Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

21 January 2018

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SHP-2 promoting migration and metastasis of MCF-7 with loss of E-cadherin, dephosphorylation of FAK and secretion of MMP-9 induced by IL-1beta in vivo and in vitro.

21 January 2018

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Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients

21 January 2018

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If you don't look, you won't see: intravital multiphoton imaging of primary and metastatic breast cancer

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Real-time intravital imaging of cancer models

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Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models

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Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts

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Cell migration in tumors

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Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

21 January 2018

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c-Src and cooperating partners in human cancer

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Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor

21 January 2018

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Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion

21 January 2018

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Phosphotyrosine (p-Tyr)-dependent and -independent mechanisms of p190 RhoGAP-p120 RasGAP interaction: Tyr 1105 of p190, a substrate for c-Src, is the sole p-Tyr mediator of complex formation

21 January 2018

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p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IV

21 January 2018

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Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration

21 January 2018

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Src family kinases are required for integrin but not PDGFR signal transduction.

21 January 2018

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Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics

21 January 2018

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The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

21 January 2018

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Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion

21 January 2018

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Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility

21 January 2018

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The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration

21 January 2018

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Lung metastasis genes couple breast tumor size and metastatic spread.

21 January 2018

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JAK2/STAT5 inhibition circumvents resistance to PI3K/mTOR blockade: a rationale for cotargeting these pathways in metastatic breast cancer

21 January 2018

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Methods for cell and particle tracking

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Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis

21 January 2018

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Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24931162

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24931162

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Tyrosine phosphorylation of paxillin alpha is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24931162