KSR1 regulates BRCA1 degradation and inhibits breast cancer growth (Q38987139)

8 September 2017

KSR1 regulates BRCA1 degradation and inhibits breast cancer growth (English)

1 reference

8 September 2017

1

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7 June 2020

Andrew Green

5

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7 June 2020

Kevin Blighe

9

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7 June 2020

Jacqui A Shaw

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7 June 2020

Ian Ellis

12

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7 June 2020

Georgios Giamas

14

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7 June 2020

author name string

H Zhang

2

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7 June 2020

Y Xu

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7 June 2020

L C Lit

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7 June 2020

A Grothey

6

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7 June 2020

Y Lombardo

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7 June 2020

M Periyasamy

8

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7 June 2020

W Zhang

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7 June 2020

H J Lenz

13

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7 June 2020

language of work or name

English

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publication date

9 June 2014

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8 September 2017

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7 June 2020

volume

34

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7 June 2020

issue

16

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7 June 2020

page(s)

2103-2114

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https://scigraph.springernature.com/pub.10.1038/onc.2014.129

7 June 2020

exact match

0 references

cites work

Endocrine-responsive breast cancer and strategies for combating resistance

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

KSR, a novel protein kinase required for RAS signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Inflammatory bowel disease reveals the kinase activity of KSR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Kinase suppressor of Ras transphosphorylates c-Raf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

The dual function of KSR1: a pseudokinase and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

The role of pseudokinases in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Blocking oncogenic Ras signaling for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Comparative oncogenomics implicates the neurofibromin 1 gene (NF1) as a breast cancer driver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Is there more to BARD1 than BRCA1?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

ONCOMINE: a cancer microarray database and integrated data-mining platform

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Stromal gene expression predicts clinical outcome in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Gene expression profiling of the tumor microenvironment during breast cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

X chromosomal abnormalities in basal-like human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Genomic analysis of circulating cell-free DNA infers breast cancer dormancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

A dimerization-dependent mechanism drives RAF catalytic activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

RAF inhibitor-induced KSR1/B-RAF binding and its effects on ERK cascade signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

How scaffolds shape MAPK signaling: what we know and opportunities for systems approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Identification of DBC1 as a transcriptional repressor for BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Histologic grading of breast cancer: linkage of patient outcome with level of pathologist agreement

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

LMTK3 expression in breast cancer: association with tumor phenotype and clinical outcome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

The proteins FABP7 and OATP2 are associated with the basal phenotype and patient outcome in human breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

The MAPK scaffold kinase suppressor of Ras is involved in ERK activation by stress and proinflammatory cytokines and induction of arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2014.129

Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24909178

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24909178