Advances in structure-based drug discovery of carbonic anhydrase inhibitors (Q38991378)

8 September 2017

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title

Advances in structure-based drug discovery of carbonic anhydrase inhibitors (English)

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8 September 2017

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1

Claudiu T Supuran

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8 September 2017

language of work or name

English

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publication date

26 October 2016

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Expert Opinion on Drug Discovery

8 September 2017

published in

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8 September 2017

volume

12

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8 September 2017

issue

1

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8 September 2017

page(s)

61-88

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Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

8 September 2017

cites work

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Interfering with pH regulation in tumours as a therapeutic strategy

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Structure-based drug discovery of carbonic anhydrase inhibitors

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Structure and function of carbonic anhydrases

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(In)organic anions as carbonic anhydrase inhibitors

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Thylakoid luminal θ-carbonic anhydrase critical for growth and photosynthesis in the marine diatom Phaeodactylum tricornutum

21 January 2018

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Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases

21 January 2018

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Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms?

21 January 2018

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Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.

21 January 2018

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Novel therapies for glaucoma: a patent review 2007 - 2011.

21 January 2018

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Antiglaucoma carbonic anhydrase inhibitors: a patent review

21 January 2018

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Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 - 2013).

21 January 2018

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Antiobesity carbonic anhydrase inhibitors: a literature and patent review

21 January 2018

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The anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog strongly inhibit carbonic anhydrases: solution and X-ray crystallographic studies

21 January 2018

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Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

21 January 2018

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Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

21 January 2018

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Acetazolamide for the treatment of idiopathic intracranial hypertension

21 January 2018

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A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects

21 January 2018

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Carbonic anhydrase inhibition and the management of neuropathic pain

21 January 2018

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Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors.

21 January 2018

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Overexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium

21 January 2018

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Sulfa and trimethoprim-like drugs - antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors

21 January 2018

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Legionella pneumophila Carbonic Anhydrases: Underexplored Antibacterial Drug Targets

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Inhibition of carbonic anhydrase from Trypanosoma cruzi for the management of Chagas disease: an underexplored therapeutic opportunity

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase catalyzes cyanamide hydration to urea: is it mimicking the physiological reaction?

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Crystal structure and kinetic studies of a tetrameric type II β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

The zinc coordination pattern in the η-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

How many carbonic anhydrase inhibition mechanisms exist?

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Inhibition of the β-carbonic anhydrases from Mycobacterium tuberculosis with C-cinnamoyl glycosides: identification of the first inhibitor with anti-mycobacterial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins

21 January 2018

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The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Novel coumarins and benzocoumarins acting as isoform-selective inhibitors against the tumor-associated carbonic anhydrase IX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibits α-carbonic anhydrases without hydrolysis of the lactam ring.

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Out of the active site binding pocket for carbonic anhydrase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Synthesis of 3,4-dihydroxypyrrolidine-2,5-dione and 3,5-dihydroxybenzoic acid derivatives and evaluation of the carbonic anhydrase I and II inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Superacid synthesis of halogen containing N-substituted-4-aminobenzene sulfonamides: new selective tumor-associated carbonic anhydrase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

New superacid synthesized (fluorinated) tertiary benzenesulfonamides acting as selective hCA IX inhibitors: toward a new mode of carbonic anhydrase inhibition by sulfonamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Nanoscale enzyme inhibitors: fullerenes inhibit carbonic anhydrase by occluding the active site entrance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors, interaction of boron derivatives with isozymes I and II: a new binding site for hydrophobic inhibitors at the entrance of the active site as shown by docking studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors: allylsulfonamide, styrene sulfonamide, N-allyl sulfonamides and some of their Si, Ge, and B derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isoforms I and II and transmembrane, tumor-associated isoforms IX and XII with boronic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Benzoxaborole as a new chemotype for carbonic anhydrase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Bortezomib inhibits bacterial and fungal β-carbonic anhydrases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Dipotassium-trioxohydroxytetrafluorotriborate, K₂[B₃O₃F₄OH], is a potent inhibitor of human carbonic anhydrases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. Part 91. Metal complexes of heterocyclic sulfonamides as potential pharmacological agents in the treatment of gastric Acid secretion imbalances

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Synthesis of sulfonamide conjugates of Cu(II), Ga(III), In(III), Re(V) and Zn(II) complexes: carbonic anhydrase inhibition studies and cellular imaging investigations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

PET Imaging of Carbonic Anhydrase IX Expression of HT-29 Tumor Xenograft Mice with (68)Ga-Labeled Benzenesulfonamides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Synthesis and in Vivo Biological Evaluation of (68)Ga-Labeled Carbonic Anhydrase IX Targeting Small Molecules for Positron Emission Tomography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Effects of cryoprotectants on the structure and thermostability of the human carbonic anhydrase II-acetazolamide complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Virtual screening-driven identification of human carbonic anhydrase inhibitors incorporating an original, new pharmacophore

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Synthesis and carbonic anhydrase inhibitory effects of new N-glycosylsulfonamides incorporating the phenol moiety.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

New natural product carbonic anhydrase inhibitors incorporating phenol moieties

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Salen and tetrahydrosalen derivatives act as effective inhibitors of the tumor-associated carbonic anhydrase XII--a new scaffold for designing isoform-selective inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. Phenols incorporating 2- or 3-pyridyl-ethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae β-carbonic anhydrase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Synthesis and carbonic anhydrase isoenzymes I, II, IX, and XII inhibitory effects of dimethoxybromophenol derivatives incorporating cyclopropane moieties

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

An Update on Natural Products with Carbonic Anhydrase Inhibitory Activity

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Structural elucidation of the hormonal inhibition mechanism of the bile acid cholate on human carbonic anhydrase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Native State Mass Spectrometry, Surface Plasmon Resonance, and X-ray Crystallography Correlate Strongly as a Fragment Screening Combination

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitory activity of sulfonamides and carboxylic acids incorporating cyclic imide scaffolds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff's bases incorporating sulfonamide, carboxylate and carboxymethyl moieties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Inhibition of α-class cytosolic human carbonic anhydrases I, II, IX and XII, and β-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Inhibition of the β-class carbonic anhydrases from Mycobacterium tuberculosis with carboxylic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with aliphatic and aromatic carboxylates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Hit Recycling: Discovery of a Potent Carbonic Anhydrase Inhibitor by in Silico Target Fishing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Natural product polyamines that inhibit human carbonic anhydrases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Mechanism of cyanamide hydration catalyzed by carbonic anhydrase II suggested by cryogenic X-ray diffraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Hydroxyurea is a carbonic anhydrase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating succinyl hydroxamate and iminodiacetic acid hydroxamate moieties

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Isomerization of the binary complex of reduced acetylpyridine adenine dinucleotide and chicken H4 lactate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Crystal structure of the complex between human carbonic anhydrase II and the aromatic inhibitor 1,2,4-triazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbamoylphosphonates control tumor cell proliferation and dissemination by simultaneously inhibiting carbonic anhydrase IX and matrix metalloproteinase-2. Toward nontoxic chemotherapy targeting tumor microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic Anhydrase Interaction With Lipothioars Enites: A Novel Class of Isozymes I and II Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV with heterocyclic mercaptans, sulfenamides, sulfonamides and their metal complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Design, synthesis, and docking studies of new 1,3,4-thiadiazole-2-thione derivatives with carbonic anhydrase inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Leishmania donovani chagasi, the protozoan parasite responsible for leishmaniasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II-trithiocarbonate adduct--an inhibitor mimicking the sulfonamide and urea binding to the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Dithiocarbamates with potent inhibitory activity against the Saccharomyces cerevisiae β-carbonic anhydrase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors: two-prong versus mono-prong inhibitors of isoforms I, II, IX, and XII exemplified by photochromic cis-1,2-alpha-dithienylethene derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors with dual-tail moieties to match the hydrophobic and hydrophilic halves of the carbonic anhydrase active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Hydrophobic substituents of the phenylmethylsulfamide moiety can be used for the development of new selective carbonic anhydrase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

A class of 4-sulfamoylphenyl-ω-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Trimeric Radiofluorinated Sulfonamide Derivatives to Achieve In Vivo Selectivity for Carbonic Anhydrase IX-Targeted PET Imaging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

[(18)F]VM4-037 MicroPET Imaging and Biodistribution of Two In Vivo CAIX-Expressing Tumor Models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Development and biological evaluation of ⁹⁹mTc-sulfonamide derivatives for in vivo visualization of CA IX as surrogate tumor hypoxia markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Novel organometallic cationic ruthenium(II) pentamethylcyclopentadienyl benzenesulfonamide complexes targeted to inhibit carbonic anhydrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

[(Cp-R)M(CO)3] (M=Re or 99mTc) Arylsulfonamide, arylsulfamide, and arylsulfamate conjugates for selective targeting of human carbonic anhydrase IX

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

N-Nitrosulfonamides: A new chemotype for carbonic anhydrase inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Structural Insights on Carbonic Anhydrase Inhibitory Action, Isoform Selectivity, and Potency of Sulfonamides and Coumarins Incorporating Arylsulfonylureido Groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Protein–Protein Interactions: Inhibition of Mammalian Carbonic Anhydrases I–XV by the Murine Inhibitor of Carbonic Anhydrase and Other Members of the Transferrin Family

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

5- and 6-Membered (thio)lactones are prodrug type carbonic anhydrase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. Inhibition of the fungal β-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors: guaiacol and catechol derivatives effectively inhibit certain human carbonic anhydrase isoenzymes (hCA I, II, IX and XII)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

N-Hydroxyurea—A versatile zinc binding function in the design of metalloenzyme inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic Anhydrase and Matrix Metalloproteinase Inhibitors: Sulfonylated Amino Acid Hydroxamates with MMP Inhibitory Properties Act as Efficient Inhibitors of CA Isozymes I, II, and IV, andN-Hydroxysulfonamides Inhibit Both These Zinc Enzymes1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors: Inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozymes I and II with some 1,3,4-oxadiazole-thiols

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II and IX with some 1,3,4-oxadiazole- and 1,2,4-triazole-thiols

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Cloning, Characterization, and Sulfonamide and Thiol Inhibition Studies of an α-Carbonic Anhydrase from Trypanosoma cruzi, the Causative Agent of Chagas Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Carbonic Anhydrase Inhibitors. Synthesis of Water-Soluble, Topically Effective, Intraocular Pressure-Lowering Aromatic/Heterocyclic Sulfonamides Containing Cationic or Anionic Moieties: Is the Tail More Important than the Ring?1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Metallocene-Based Inhibitors of Cancer-Associated Carbonic Anhydrase Enzymes IX and XII

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

Sulfonamides incorporating heteropolycyclic scaffolds show potent inhibitory action against carbonic anhydrase isoforms I, II, IX and XII

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2017.1253677

10.1080/17460441.2017.1253677

21 January 2018

Identifiers

DOI

1 reference

8 September 2017

1 reference