The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism (Q38992755)

8 September 2017

The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism (English)

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Christian von Loeffelholz

8 September 2017

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1

Christian von Loeffelholz

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Christoph Harms

Christoph Harms

17

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Igor M Sauer

Igor M Sauer

6

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Gerald I. Shulman

Gerald I Shulman

22

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Antonios Chatzigeorgiou

Antonios Chatzigeorgiou

10

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Nathanael Raschzok

Nathanael Raschzok

5

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Stefan R. Bornstein

15

Stefan R Bornstein

1 reference

8 September 2017

Triantafyllos Chavakis

23

Triantafyllos Chavakis

1 reference

8 September 2017

Christian von Loeffelholz

1

1 reference

8 September 2017

Stefanie Lieske

2

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8 September 2017

Frank Neuschäfer-Rube

3

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8 September 2017

Diana M Willmes

4

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8 September 2017

Jörg König

7

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8 September 2017

Martin F Fromm

8

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8 September 2017

Paul Horn

9

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8 September 2017

Andrea Pathe-Neuschäfer-Rube

11

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8 September 2017

Jens Jordan

12

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8 September 2017

Andreas F H Pfeiffer

13

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8 September 2017

Geltrude Mingrone

14

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8 September 2017

Peter Stroehle

16

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8 September 2017

F Thomas Wunderlich

18

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8 September 2017

Stephen L Helfand

19

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8 September 2017

Michel Bernier

20

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8 September 2017

Rafael de Cabo

21

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8 September 2017

Gerhard P Püschel

24

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8 September 2017

Andreas L Birkenfeld

25

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8 September 2017

language of work or name

English

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publication date

30 January 2017

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8 September 2017

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8 September 2017

66

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8 September 2017

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8 September 2017

616-630

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Extended life-span conferred by cotransporter gene mutations in Drosophila.

8 September 2017

1 reference

Functional features and genomic organization of mouse NaCT, a sodium-coupled transporter for tricarboxylic acid cycle intermediates

21 January 2018

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Long-lived Indy and calorie restriction interact to extend life span.

21 January 2018

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Knockdown of Indy/CeNac2 extends Caenorhabditis elegans life span by inducing AMPK/aak-2

21 January 2018

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Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage

21 January 2018

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Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy

21 January 2018

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Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice

21 January 2018

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Indy mutants: live long and prosper.

21 January 2018

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Structure, function, and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain

21 January 2018

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Functional identity of Drosophila melanogaster Indy as a cation-independent, electroneutral transporter for tricarboxylic acid-cycle intermediates

21 January 2018

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Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines

21 January 2018

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The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes

21 January 2018

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Structure and mechanism of a bacterial sodium-dependent dicarboxylate transporter

21 January 2018

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Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)

21 January 2018

1 reference

Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5).

21 January 2018

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A stress signaling pathway in adipose tissue regulates hepatic insulin resistance

21 January 2018

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Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes.

21 January 2018

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Immunometabolism: an emerging frontier

21 January 2018

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Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

21 January 2018

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Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

21 January 2018

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Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action

21 January 2018

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Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction

21 January 2018

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Elevated hepatic chemerin mRNA expression in human non-alcoholic fatty liver disease

21 January 2018

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Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.

21 January 2018

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SLC13A5 is a novel transcriptional target of the pregnane X receptor and sensitizes drug-induced steatosis in human liver

21 January 2018

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Citrate--new functions for an old metabolite

21 January 2018

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Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes

21 January 2018

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Inflammatory links between obesity and metabolic disease

21 January 2018

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Noninvasive biomarkers for the diagnosis of steatohepatitis and advanced fibrosis in NAFLD.

21 January 2018

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Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice

21 January 2018

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Electrophysiological characterization of human and mouse sodium-dependent citrate transporters (NaCT/SLC13A5) reveal species differences with respect to substrate sensitivity and cation dependence

21 January 2018

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Relevance of NAC-2, an Na+-coupled citrate transporter, to life span, body size and fat content in Caenorhabditis elegans

21 January 2018

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No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects

21 January 2018

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Type 2 diabetes as an inflammatory disease

21 January 2018

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Adipokines in liver diseases

21 January 2018

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Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

21 January 2018

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Human IL6 enhances leptin action in mice

21 January 2018

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Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes

21 January 2018

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Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease

21 January 2018

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Chronic IL-6 Administration Desensitizes IL-6 Response in Liver, Causes Hyperleptinemia and Aggravates Steatosis in Diet-Induced-Obese Mice

21 January 2018

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Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice

21 January 2018

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Blockade of interleukin 6 signalling ameliorates systemic insulin resistance through upregulation of glucose uptake in skeletal muscle and improves hepatic steatosis in high-fat diet fed mice.

21 January 2018

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Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family

21 January 2018

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Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice

21 January 2018

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Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action

21 January 2018

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Search for mediators of the lipogenic effects of tumor necrosis factor: potential role for interleukin 6.

21 January 2018

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12 December 2020

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

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12 December 2020

IL-6 and IGF-1 are independent prognostic factors of liver steatosis and non-alcoholic steatohepatitis in morbidly obese patients

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12 December 2020

IL-6-deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver.

1 reference

12 December 2020

The good, the bad, and the ugly of interleukin-6 signaling.

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12 December 2020

Identifiers

DOI

10.1002/HEP.29089

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8 September 2017

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