IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice. (Q39003110)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24744051%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

title

IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice (English)

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14 March 2020

1

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14 March 2020

Danielle E. Dye

2

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14 March 2020

Delia J. Nelson

3

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14 March 2020

author name string

C Jackaman

1

1 reference

8 September 2017

D E Dye

2

1 reference

8 September 2017

D J Nelson

3

1 reference

8 September 2017

19 April 2014

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14 March 2020

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14 March 2020

volume

36

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14 March 2020

issue

3

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14 March 2020

page(s)

9655

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Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy

14 March 2020

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9 September 2017

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9 September 2017

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Malignant Mesothelioma: Global Incidence and Relationship with Asbestos

9 September 2017

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Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis

9 September 2017

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9 September 2017

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Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes

9 September 2017

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The chemokine system in diverse forms of macrophage activation and polarization

9 September 2017

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Determination of lymphocyte division by flow cytometry

9 September 2017

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Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice.

9 September 2017

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Chemotherapy broadens the range of tumor antigens seen by cytotoxic CD8(+) T cells in vivo.

9 September 2017

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IL-2/CD40-driven NK cells install and maintain potency in the anti-mesothelioma effector/memory phase

9 September 2017

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Intratumoral interleukin-2/agonist CD40 antibody drives CD4+ -independent resolution of treated-tumors and CD4+ -dependent systemic and memory responses.

9 September 2017

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In aged mice, outgrowth of intraocular melanoma depends on proangiogenic M2-type macrophages.

9 September 2017

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Cytokine-armed vaccinia virus infects the mesothelioma tumor microenvironment to overcome immune tolerance and mediate tumor resolution

14 September 2017

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Local effector failure in mesothelioma is not mediated by CD4+ CD25+ T-regulator cells.

14 September 2017

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Deliberately provoking local inflammation drives tumors to become their own protective vaccine site.

14 September 2017

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Functional endogenous cytotoxic T lymphocytes are generated to multiple antigens co-expressed by progressing tumors; after intra-tumoral IL-2 therapy these effector cells eradicate established tumors

14 September 2017

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Intratumoral poly-N-acetyl glucosamine-based polymer matrix provokes a prolonged local inflammatory response that, when combined with IL-2, induces regression of malignant mesothelioma in a murine model.

14 September 2017

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IL-2 intratumoral immunotherapy enhances CD8+ T cells that mediate destruction of tumor cells and tumor-associated vasculature: a novel mechanism for IL-2.

14 September 2017

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Macrophages but not B cells from aged mice are defective in stimulating autoreactive T cells in vitro

14 September 2017

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Establishment of a murine model of malignant mesothelioma

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Circulating and tumor-infiltrating myeloid cells predict survival in human pleural mesothelioma.

17 June 2018

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21 August 2018

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21 August 2018

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21 August 2018

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21 August 2018

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Critical role of the Th1/Tc1 circuit for the generation of tumor-specific CTL during tumor eradication in vivo by Th1-cell therapy.

21 August 2018

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Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumor-specific CD8 T cells

21 August 2018

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Efficacy of cancer gene therapy in aging: adenocarcinoma cells engineered to release IL-2 are rejected but do not induce tumor specific immune memory in old mice

21 August 2018

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A defective protein kinase C anchoring system underlying age-associated impairment in TNF-alpha production in rat macrophages

21 August 2018

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Decreases in macrophage mediated antitumor activity with aging

21 August 2018

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Superoxide generation by alveolar macrophages from aged rats: improvement by in vitro treatment with IFN-gamma

21 August 2018

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12 December 2020

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12 December 2020

Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response

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12 December 2020

Delayed but excellent myogenic stem cell response of regenerating geriatric skeletal muscles in mice

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12 December 2020

Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells

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12 December 2020

10.1007/S11357-014-9655-Y

Identifiers

DOI

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14 March 2020

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14 March 2020

PubMed publication ID

24744051

1 reference

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