BMP4 promotes EMT and mesodermal commitment in human embryonic stem cells via SLUG and MSX2. (Q39022844)

8 September 2017

title

BMP4 promotes EMT and mesodermal commitment in human embryonic stem cells via SLUG and MSX2. (English)

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human embryonic stem cell

8 September 2017

main subject

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based on heuristic

inferred from title

author

Gudrun Valdimarsdottir

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Gudrun Valdimarsdottir

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Christine Mummery

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Christine Mummery

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author name string

Anne Richter

1

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Lena Valdimarsdottir

2

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Helga Eyja Hrafnkelsdottir

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Johann Frimann Runarsson

4

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Arna Run Omarsdottir

5

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Dorien Ward-van Oostwaard

6

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8 September 2017

publication date

1 March 2014

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8 September 2017

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volume

32

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issue

3

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8 September 2017

page(s)

636-648

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Functions of the TGFbeta superfamily in human embryonic stem cells

8 September 2017

cites work

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Cardiomyocytes from human pluripotent stem cells in regenerative medicine and drug discovery

21 January 2018

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Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells

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Tracking the progression of the human inner cell mass during embryonic stem cell derivation.

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BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3

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TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells

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Basic fibroblast growth factor supports undifferentiated human embryonic stem cell growth without conditioned medium.

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

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The regulation of TGFbeta signal transduction

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Two major Smad pathways in TGF-beta superfamily signalling.

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Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development

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Spatio-temporal activation of Smad1 and Smad5 in vivo: monitoring transcriptional activity of Smad proteins

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Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin

21 January 2018

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Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells

21 January 2018

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Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells

21 January 2018

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Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts

21 January 2018

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Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent

21 January 2018

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Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population

21 January 2018

1 reference

Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression

21 January 2018

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Transcriptional crosstalk between TGF-β and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes

21 January 2018

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Derivation of Embryonic Stem-Cell Lines from Human Blastocysts

21 January 2018

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A protocol describing the use of a recombinant protein-based, animal product-free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies

21 January 2018

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The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4

21 January 2018

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NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs

21 January 2018

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Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.

21 January 2018

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Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling

21 January 2018

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Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors.

21 January 2018

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Bone morphogenetic protein-4 promotes induction of cardiomyocytes from human embryonic stem cells in serum-based embryoid body development

21 January 2018

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Combinatorial activin receptor-like kinase/Smad and basic fibroblast growth factor signals stimulate the differentiation of human embryonic stem cells into the cardiac lineage.

21 January 2018

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Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells

21 January 2018

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Phosphorylation dynamics during early differentiation of human embryonic stem cells.

21 January 2018

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Epithelial-mesenchymal transition process in human embryonic stem cells cultured in feeder-free conditions.

21 January 2018

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miR-124a Is Important for Migratory Cell Fate Transition During Gastrulation of Human Embryonic Stem Cells

21 January 2018

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Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis.

21 January 2018

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BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways

21 January 2018

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BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages

21 January 2018

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Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4

21 January 2018

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Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

21 January 2018

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Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

21 January 2018

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Bmp2 instructs cardiac progenitors to form the heart-valve-inducing field

21 January 2018

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A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos

21 January 2018

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High-Efficiency Induction of Neural Conversion in Human ESCs and Human Induced Pluripotent Stem Cells with a Single Chemical Inhibitor of Transforming Growth Factor Beta Superfamily Receptors

21 January 2018

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Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development

21 January 2018

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Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines

21 January 2018

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Lateral signaling enhances TGF-beta response complexity

21 January 2018

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A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts

21 January 2018

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A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog

21 January 2018

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A chemical platform for improved induction of human iPSCs

21 January 2018

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Pathogenic mutation of ALK2 inhibits induced pluripotent stem cell reprogramming and maintenance: mechanisms of reprogramming and strategy for drug identification

21 January 2018

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Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming

21 January 2018

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Feeder-Free Monolayer Cultures of Human Embryonic Stem Cells Express an Epithelial Plasma Membrane Protein Profile

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/STEM.1592

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8 September 2017

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