Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3. (Q39030338)

8 September 2017

Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3. (English)

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8 September 2017

transmembrane protein

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7

Shoshana J Wodak

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Xavier Deupí

Xavier Deupi

5

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Leonardo Pardo

Leonardo Pardo

9

0 references

Marc Parmentier

Marc Parmentier

8

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Cédric Blanpain

10

Cédric Blanpain

1 reference

8 September 2017

3

Jean-Yves Springael

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8 September 2017

6

Emmanuel Le Poul

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8 September 2017

Cédric Govaerts

1

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8 September 2017

Antoine Bondue

2

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8 September 2017

Mireia Olivella

4

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8 September 2017

language of work or name

English

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publication date

30 October 2002

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Journal of Biological Chemistry

8 September 2017

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8 September 2017

278

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8 September 2017

3

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8 September 2017

1892-1903

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Chemokines and leukocyte traffic

8 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

21 January 2018

Chemokines and disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Receptor activation: what does the rhodopsin structure tell us?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Light-induced exposure of the cytoplasmic end of transmembrane helix seven in rhodopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

G protein-coupled receptors. I. Diversity of receptor-ligand interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Functional role of tryptophan residues in the fourth transmembrane domain of the CB(2) cannabinoid receptor

21 January 2018

1 reference

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Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1a) receptor ligands to explore the three-dimensional structure of the receptor.

21 January 2018

1 reference

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Serine and threonine residues bend alpha-helices in the chi(1) = g(-) conformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Crystal structure of rhodopsin: A G protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Prediction of protein side-chain rotamers from a backbone-dependent rotamer library: a new homology modeling tool

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Influence of the environment in the conformation of alpha-helices studied by protein database search and molecular dynamics simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

The second extracellular loop of CCR5 is the major determinant of ligand specificity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Palmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Multiple active states and oligomerization of CCR5 revealed by functional properties of monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Hydrogen bonds with pi-acceptors in proteins: frequencies and role in stabilizing local 3D structures

21 January 2018

1 reference

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HIV-1 glycoprotein 120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Aromatic-aromatic interaction: a mechanism of protein structure stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Conserved HisVI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P.

21 January 2018

1 reference

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Role of the His273 located in the sixth transmembrane domain of the angiotensin II receptor subtype AT2 in ligand-receptor interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Roles of threonine 192 and asparagine 382 in agonist and antagonist interactions with M1 muscarinic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

The role of a conserved proline residue in mediating conformational changes associated with voltage gating of Cx32 gap junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

21 January 2018

1 reference

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Benzene Forms Hydrogen Bonds with Water

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Conformational changes in rhodopsin. Movement of helix f detected by site-specific chemical labeling and fluorescence spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Chloroethylclonidine and 2-Aminoethyl Methanethiosulfonate Recognize Two Different Conformations of the Human α2A-Adrenergic Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Identification of conserved aromatic residues essential for agonist binding and second messenger production at 5-hydroxytryptamine2A receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

A cluster of aromatic residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

A hydrophobic cluster between transmembrane helices 5 and 6 constrains the thyrotropin-releasing hormone receptor in an inactive conformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Dopamine D4/D2 receptor selectivity is determined by A divergent aromatic microdomain contained within the second, third, and seventh membrane-spanning segments

21 January 2018

1 reference

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An automated approach for clustering an ensemble of NMR-derived protein structures into conformationally related subfamilies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

Mutagenesis of the human 5-HT1B receptor: differences from the closely related 5-HT1A receptor and the role of residue F331 in signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205685200

21 January 2018

Identifiers

DOI

10.1074/JBC.M205685200

1 reference

8 September 2017

1 reference