Looking Beyond the 5-HTTLPR Polymorphism: Genetic and Epigenetic Layers of Regulation Affecting the Serotonin Transporter Gene Expression (Q39033887)

8 September 2017

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title

Looking Beyond the 5-HTTLPR Polymorphism: Genetic and Epigenetic Layers of Regulation Affecting the Serotonin Transporter Gene Expression (English)

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8 September 2017

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Sandra Iurescia

1

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8 September 2017

Davide Seripa

series ordinal

2

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8 September 2017

Monica Rinaldi

series ordinal

3

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8 September 2017

8 December 2016

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8 September 2017

Molecular Neurobiology

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https://scigraph.springernature.com/pub.10.1007/s12035-016-0304-6

8 September 2017

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21 January 2018

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21 January 2018

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The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants

21 January 2018

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Alternative non-coding exons support serotonin transporter mRNA expression in the brain and gut.

21 January 2018

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Epigenetic regulation of serotonin transporter in psychiatric disorders

21 January 2018

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Integrating the roles of long and small non-coding RNA in brain function and disease

21 January 2018

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New insights into the roles of microRNAs in drug addiction and neuroplasticity

21 January 2018

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Long story short: the serotonin transporter in emotion regulation and social cognition

21 January 2018

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Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits

21 January 2018

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Gene X environment interactions at the serotonin transporter locus

21 January 2018

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Epigenetic transmission of the impact of early stress across generations.

21 January 2018

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Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

21 January 2018

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Epigenetic programming by maternal behavior

21 January 2018

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Genetic and early environmental influences on the serotonin system: consequences for brain development and risk for psychopathology

21 January 2018

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Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress-diathesis model of depression

21 January 2018

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Effects of stress throughout the lifespan on the brain, behaviour and cognition

21 January 2018

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Epigenetics of the depressed brain: role of histone acetylation and methylation

21 January 2018

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The serotonin transporter intronic VNTR enhancer correlated with a predisposition to affective disorders has distinct regulatory elements within the domain based on the primary DNA sequence of the repeat unit

21 January 2018

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A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo

21 January 2018

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An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells

21 January 2018

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Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression

21 January 2018

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Correlation between serotonin uptake in human blood platelets with the 44-bp polymorphism and the 17-bp variable number of tandem repeat of the serotonin transporter

21 January 2018

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Association of the STin2 polymorphism of the serotonin transporter gene with a neurocognitive endophenotype in major depressive disorder

21 January 2018

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STin2 VNTR polymorphism is associated with comorbid tobacco use and mood disorders.

21 January 2018

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YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders

21 January 2018

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Differential regulation of the serotonin transporter gene by lithium is mediated by transcription factors, CCCTC binding protein and Y-box binding protein 1, through the polymorphic intron 2 variable number tandem repeat

21 January 2018

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The SLC6A4 VNTR genotype determines transcription factor binding and epigenetic variation of this gene in response to cocaine in vitro.

21 January 2018

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Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by CTCF.

21 January 2018

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Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationships to monoamine metabolite concentrations in CSF of healthy volunteers.

21 January 2018

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Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region

21 January 2018

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Allelic expression of serotonin transporter (SERT) mRNA in human pons: lack of correlation with the polymorphism SERTLPR.

21 January 2018

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Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia

21 January 2018

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SLC6A4 STin2 VNTR genetic polymorphism is associated with tobacco use disorder, but not with successful smoking cessation or smoking characteristics: a case control study

21 January 2018

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Association of paraoxonase (PON)1 activity, glutathione S-transferase GST T1/M1 and STin.2 polymorphisms with comorbidity of tobacco use disorder and mood disorders.

21 January 2018

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Association of a polyadenylation polymorphism in the serotonin transporter and panic disorder

21 January 2018

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Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G×G and G×E differences in health and disease.

21 January 2018

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Presence of multiple functional polyadenylation signals and a single nucleotide polymorphism in the 3' untranslated region of the human serotonin transporter gene.

21 January 2018

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Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene

21 January 2018

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Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylation in vitro

21 January 2018

1 reference

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Functional variation in the 3' untranslated region of the serotonin transporter in human and rhesus macaque

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

A potentially functional variant in the serotonin transporter gene is associated with premenopausal and perimenopausal hot flashes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Characterization of a functional polymorphism in the 3' UTR of SLC6A4 and its association with drinking intensity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Functions of DNA methylation: islands, start sites, gene bodies and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

DNA methylation as a risk factor in the effects of early life stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Prospects for epigenetic research within cohort studies of psychological disorder: a pilot investigation of a peripheral cell marker of epigenetic risk for depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Environmental stress affects DNA methylation of a CpG rich promoter region of serotonin transporter gene in a nurse cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Methylation matters: interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Effects of genetic and early environmental risk factors for depression on serotonin transporter expression and methylation profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Influence of life stress, 5-HTTLPR genotype, and SLC6A4 methylation on gene expression and stress response in healthy Caucasian males

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Association of SLC6A4 methylation with early adversity, characteristics and outcomes in depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Association study of polymorphism in the serotonin transporter gene promoter, methylation profiles, and expression in patients with major depressive disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Serotonin transporter gene methylation is associated with hippocampal gray matter volume.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Beyond genotype: serotonin transporter epigenetic modification predicts human brain function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

DNA methylation of the serotonin transporter gene (SLC6A4) is associated with brain function involved in processing emotional stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

An epigenetic mechanism links socioeconomic status to changes in depression-related brain function in high-risk adolescents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

DNA methylation of the serotonin transporter gene in peripheral cells and stress-related changes in hippocampal volume: a study in depressed patients and healthy controls.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

21 January 2018

The mammalian epigenome

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Can we observe epigenetic effects on human brain function?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Functional analysis of a novel human serotonin transporter gene promoter in immortalized raphe cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

A longitudinal study of SLC6A4 DNA promoter methylation and poststroke depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Methylation at 5HTT mediates the impact of child sex abuse on women's antisocial behavior: an examination of the Iowa adoptee sample

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Association between promoter methylation of serotonin transporter gene and depressive symptoms: a monozygotic twin study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

On the outside, looking in: a review and evaluation of the comparability of blood and brain "-omes".

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Childhood stress, serotonin transporter gene and brain structures in major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Characteristics of transposable element exonization within human and mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Alu elements contain many binding sites for transcription factors and may play a role in regulation of developmental processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Role of histone acetylation in the control of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

DNA methylation and histone modifications: teaming up to silence genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Regulation of intestinal serotonin transporter expression via epigenetic mechanisms: role of HDAC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

The serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: potential roles in genetic selection and gene × environment interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

MicroRNA-24 inhibits serotonin reuptake transporter expression and aggravates irritable bowel syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Decoding the non-coding genome: elucidating genetic risk outside the coding genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-016-0304-6

Neuronal circuit regulation of the hypothalamo-pituitary-adrenocortical stress axis.

21 January 2018

1 reference

12 December 2020

Early experience and serotonin transporter gene variation interact to influence primate CNS function.

1 reference

12 December 2020

Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites

1 reference

12 December 2020

Study of the association of serotonin transporter triallelic 5-HTTLPR and STin2 VNTR polymorphisms with lithium prophylaxis response in bipolar disorder

1 reference

12 December 2020

Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective disorder

1 reference

12 December 2020

Alternative splicing of the human serotonin transporter gene

1 reference

12 December 2020

Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder

1 reference

12 December 2020

Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals

1 reference

12 December 2020

10.1007/S12035-016-0304-6

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