Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction. (Q39037345)

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4 March 2020

title

Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction (English)

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19

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4 March 2020

author name string

Aidan G Gilmartin

1

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Thomas H Faitg

2

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Mark Richter

3

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4 March 2020

Arthur Groy

4

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4 March 2020

Mark A Seefeld

5

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Michael G Darcy

6

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4 March 2020

Xin Peng

7

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4 March 2020

Kelly Federowicz

8

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Jingsong Yang

9

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Shu-Yun Zhang

10

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Elisabeth Minthorn

11

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Jon-Paul Jaworski

12

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Michael Schaber

13

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Stan Martens

14

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Dean E McNulty

15

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Robert H Sinnamon

16

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4 March 2020

Hong Zhang

17

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4 March 2020

Robert B Kirkpatrick

18

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Guanglei Cui

20

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Beth Pietrak

21

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Elsie Diaz

22

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Amber Jones

23

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Martin Brandt

24

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Benjamin Schwartz

25

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Dirk A Heerding

26

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4 March 2020

Rakesh Kumar

27

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4 March 2020

publication date

5 January 2014

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4 March 2020

published in

Nature Chemical Biology

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volume

10

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issue

3

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4 March 2020

page(s)

181-187

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https://scigraph.springernature.com/pub.10.1038/nchembio.1427

4 March 2020

exact match

0 references

cites work

PPM1D is a potential target for 17q gain in neuroblastoma

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12 December 2020

Regulation of the Wip1 phosphatase and its effects on the stress response.

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12 December 2020

PPM1D is a potential therapeutic target in ovarian clear cell carcinomas

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The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.

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12 December 2020

A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.

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12 December 2020

PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study

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12 December 2020

The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases

1 reference

12 December 2020

An alternate conformation and a third metal in PstP/Ppp, the M. tuberculosis PP2C-Family Ser/Thr protein phosphatase

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12 December 2020

Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation.

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12 December 2020

The therapeutic potential of phosphatase inhibitors

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12 December 2020

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

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12 December 2020

Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets.

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12 December 2020

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

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12 December 2020

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

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12 December 2020

Development of a substrate-based cyclic phosphopeptide inhibitor of protein phosphatase 2Cdelta, Wip1

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12 December 2020

Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

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12 December 2020

Increased wild-type p53-induced phosphatase 1 (Wip1 or PPM1D) expression correlated with downregulation of checkpoint kinase 2 in human gastric carcinoma

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12 December 2020

Oncogenic phosphatase Wip1 is a novel prognostic marker for lung adenocarcinoma patient survival

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12 December 2020

Design, synthesis and selection of DNA-encoded small-molecule libraries

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12 December 2020

Tiling path genomic profiling of grade 3 invasive ductal breast cancers

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Genetic alterations and oncogenic pathways associated with breast cancer subtypes

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Systematic and quantitative assessment of the ubiquitin-modified proteome

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12 December 2020

The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours

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12 December 2020

The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.

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12 December 2020

The expanding field of SILAC.

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12 December 2020

A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles

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12 December 2020

Structural analysis of the PP2C phosphatase tPphA from Thermosynechococcus elongatus: a flexible flap subdomain controls access to the catalytic site

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12 December 2020

Substrate specificity of the human protein phosphatase 2Cdelta, Wip1

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12 December 2020

Binding of a third metal ion by the human phosphatases PP2Cα and Wip1 is required for phosphatase activity

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12 December 2020

Characterization of the active site and a unique uncompetitive inhibitor of the PPM1-type protein phosphatase PPM1D.

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12 December 2020

Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control

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12 December 2020

Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).

1 reference

12 December 2020

Wip1-dependent signaling pathways in health and diseases

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1427

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEMBIO.1427

1 reference

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4 March 2020

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