Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: hints for collateral sensitivity (Q39084283)

8 September 2017

title

Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: hints for collateral sensitivity (English)

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8 September 2017

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8 September 2017

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8 September 2017

Marialessandra Contino

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8 September 2017

Amalia Azzariti

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Roberto Perrone

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Roberto Perrone

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author name string

Savina Ferorelli

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8 September 2017

Nicola Antonio Colabufo

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8 September 2017

Francesco Berardi

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8 September 2017

publication date

19 September 2013

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8 September 2017

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8 September 2017

volume

8

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8 September 2017

issue

12

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8 September 2017

page(s)

2026-2035

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Pharmacology and therapeutic potential of sigma(1) receptor ligands

8 September 2017

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Is the sigma2 receptor a histone binding protein?

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Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site.

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Sigma-2 receptors as a biomarker of proliferation in solid tumours

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Classes of sigma2 (σ2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity

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Sigma-2 ligands induce tumour cell death by multiple signalling pathways.

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Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress.

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2-Aminopyridine derivatives as potential σ(2) receptor antagonists

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Arylamides hybrids of two high-affinity σ2 receptor ligands as tools for the development of PET radiotracers

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Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers

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1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Δ(8)-Δ(7) sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity

21 January 2018

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Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).

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Synthesis and pharmacological evaluation of indole-based sigma receptor ligands

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Substituted benzylaminoalkylindoles with preference for the sigma2 binding site.

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Design and evaluation of naphthol- and carbazole-containing fluorescent sigma ligands as potential probes for receptor binding studies.

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F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells

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Pharmacological strategies for overcoming multidrug resistance

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4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity

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Design, synthesis, and evaluation of new chemosensitizers in multi-drug-resistant Plasmodium falciparum

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1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 (sigma1) and sigma-2 (sigma2) receptor ligands: a review

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Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors

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Synthesis and structure-activity evaluation of isatin-β-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein

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Collateral sensitivity as a strategy against cancer multidrug resistance

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Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonism

21 January 2018

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Antiproliferative and cytotoxic effects of some sigma2 agonists and sigma1 antagonists in tumour cell lines

21 January 2018

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Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer.

21 January 2018

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In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system

21 January 2018

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A proposal for the classification of sigma binding sites

21 January 2018

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7 January 2021

Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles

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7 January 2021

Overcoming Multidrug Resistance in Cancer: An Update on the Clinical Strategy of Inhibiting P-Glycoprotein

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7 January 2021

Measurement of cytotoxicity by ATP-based luminescence assay in primary cell cultures and cell lines

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7 January 2021

Identifiers

DOI

10.1002/CMDC.201300291

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8 September 2017

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