Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence (Q39088576)

9 September 2017

Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence (English)

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9 September 2017

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resveratrol-3-O-sulfate

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ChEBI release 2020-05-28

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Ketan R Patel

1

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9 September 2017

Catherine Andreadi

2

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9 September 2017

Robert G Britton

3

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9 September 2017

Emma Horner-Glister

4

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9 September 2017

Ankur Karmokar

5

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9 September 2017

Stewart Sale

6

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9 September 2017

Victoria A Brown

7

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9 September 2017

Dean E Brenner

8

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9 September 2017

Rajinder Singh

9

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9 September 2017

William P Steward

10

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9 September 2017

Andreas J Gescher

11

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9 September 2017

Karen Brown

12

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9 September 2017

language of work or name

English

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publication date

1 October 2013

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Science Translational Medicine

9 September 2017

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9 September 2017

5

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9 September 2017

205ra133

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9 September 2017

205

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Therapeutic potential of resveratrol: the in vivo evidence

9 September 2017

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Resveratrol as a therapeutic agent for neurodegenerative diseases

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Resveratrol improves health and survival of mice on a high-calorie diet

21 January 2018

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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

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What is new for an old molecule? Systematic review and recommendations on the use of resveratrol

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Resveratrol: challenges in translation to the clinic--a critical discussion.

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Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent

21 January 2018

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Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis

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Clinical trials of resveratrol

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Resveratrol metabolites do not elicit early pro-apoptotic mechanisms in neuroblastoma cells

21 January 2018

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Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activity

21 January 2018

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Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.

21 January 2018

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Pleiotropic mechanisms facilitated by resveratrol and its metabolites.

21 January 2018

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Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients.

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Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography

21 January 2018

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Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate.

21 January 2018

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Human hepatic cell uptake of resveratrol: involvement of both passive diffusion and carrier-mediated process

21 January 2018

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Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3.

21 January 2018

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Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol

21 January 2018

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Autophagy mediates the mitotic senescence transition

21 January 2018

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Connecting autophagy to senescence in pathophysiology.

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Dual aromatase-steroid sulfatase inhibitors

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Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors

21 January 2018

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Genistein and resveratrol, alone and in combination, suppress prostate cancer in SV-40 tag rats

21 January 2018

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The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice.

21 January 2018

1 reference

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

21 January 2018

1 reference

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Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

21 January 2018

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Antitumor activity of resveratrol and its sulfated metabolites against human breast cancer cells

21 January 2018

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OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

21 January 2018

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Expression of sulfotransferases and sulfatases in human breast cancer: impact on resveratrol metabolism

21 January 2018

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Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition

21 January 2018

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Overexpression of OATP1B3 confers apoptotic resistance in colon cancer

21 January 2018

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The expression and function of organic anion transporting polypeptides in normal tissues and in cancer

21 January 2018

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AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.

21 January 2018

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Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson's disease

21 January 2018

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Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity

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Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

21 January 2018

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Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities

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Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation

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Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy

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Cellular senescence as a tumor-suppressor mechanism

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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

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Chronic treatment with resveratrol induces redox stress- and ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells.

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A concise synthesis of glucuronide metabolites of urolithin-B, resveratrol, and hydroxytyrosol.

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10.1126/SCITRANSLMED.3005870

21 January 2018

Identifiers

DOI

1 reference

9 September 2017

1 reference