The LIM domain only 4 protein is a metabolic responsive inhibitor of protein tyrosine phosphatase 1B that controls hypothalamic leptin signaling. (Q39117221)

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scientific article published on July 2013

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English	The LIM domain only 4 protein is a metabolic responsive inhibitor of protein tyrosine phosphatase 1B that controls hypothalamic leptin signaling.	scientific article published on July 2013

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6 March 2020

The LIM domain only 4 protein is a metabolic responsive inhibitor of protein tyrosine phosphatase 1B that controls hypothalamic leptin signaling (English)

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6 March 2020

Alexandre F. Stewart

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Hsiao-Huei Chen

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Nihar R Pandey

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Xun Zhou

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Zhaohong Qin

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Tariq Zaman

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Mariana Gomez-Smith

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Kianoosh Keyhanian

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Hymie Anisman

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Jean Michel Brunel

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1 July 2013

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Journal of Neuroscience

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12647-12655

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describes a project that uses

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11 June 2022

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Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction

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https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

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The role of SOCS-3 in leptin signaling and leptin resistance

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Role of brain insulin receptor in control of body weight and reproduction

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Palmitate-induced apoptosis can occur through a ceramide-independent pathway

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Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade

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Oxidation of zinc finger transcription factors: physiological consequences

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12 December 2020

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The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer.

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Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

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12 December 2020

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PTP1B regulates leptin signal transduction in vivo

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https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

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The release of pancreatic glucagon and inhibition of insulin in response to stimulation of the sympathetic innervation

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12 December 2020

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Appetite suppression and weight reduction by a centrally active aminosterol.

1 reference

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12 December 2020

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Differential expression of a transcription regulatory factor, the LIM domain only 4 protein Lmo4, in muscle sensory neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

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Dendrite development regulated by CREST, a calcium-regulated transcriptional activator

1 reference

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12 December 2020

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Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

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12 December 2020

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Diabetes, obesity, and the brain

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12 December 2020

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Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction

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12 December 2020

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Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

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https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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Neuronal deletion of Lepr elicits diabesity in mice without affecting cold tolerance or fertility

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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Neuronal PTP1B regulates body weight, adiposity and leptin action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

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Assays of protein palmitoylation

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https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

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Palmitoylation: policing protein stability and traffic

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

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The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

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LMO4 mRNA stability is regulated by extracellular ATP in F11 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

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Extracellular ATP-dependent upregulation of the transcription cofactor LMO4 promotes neuron survival from hypoxia

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12 December 2020

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Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the phosphatidylinositol 3-kinase cell survival pathway

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12 December 2020

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ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3.

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12 December 2020

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Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo

1 reference

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12 December 2020

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PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446

1 reference

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12 December 2020

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Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats

1 reference

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12 December 2020

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A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells

1 reference

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12 December 2020

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LIM-only protein 4 interacts directly with the repulsive guidance molecule A receptor Neogenin.

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Antimicrobial activities of 3-amino- and polyaminosterol analogues of squalamine and trodusquemine

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12 December 2020

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HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms

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12 December 2020

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Rescue of neurons from ischemic injury by peroxisome proliferator-activated receptor-gamma requires a novel essential cofactor LMO4

1 reference

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12 December 2020

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Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

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12 December 2020

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Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity

1 reference

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12 December 2020

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MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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LIM domain only 4 protein promotes granulocyte colony-stimulating factor-induced signaling in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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Analysis of the redox regulation of protein tyrosine phosphatase superfamily members utilizing a cysteinyl-labeling assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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Loss of LMO4 in the retina leads to reduction of GABAergic amacrine cells and functional deficits

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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ATP-mediated glucosensing by hypothalamic tanycytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

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Leptin and the central nervous system control of glucose metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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Ablation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

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Signalling by protein phosphatases and drug development: a systems-centred view.

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12 December 2020

based on heuristic

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LIM domain only 4 (LMO4) regulates calcium-induced calcium release and synaptic plasticity in the hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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Extracellular ATP-stimulated macrophages produce macrophage inflammatory protein-2 which is important for neutrophil migration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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P2X7 receptor activation induces reactive oxygen species formation in erythroid cells

1 reference

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12 December 2020

based on heuristic

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Neuronal androgen receptor regulates insulin sensitivity via suppression of hypothalamic NF-κB-mediated PTP1B expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of hypothalamic stimulation on plasma glucose, insulin, and glucagon levels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positional cloning of the mouse obese gene and its human homologue

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal splicing of the leptin receptor in diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptin activation in hypothalamus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904601

12 December 2020

based on heuristic

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Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators

1 reference

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Identifiers

10.1523/JNEUROSCI.0746-13.2013

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6 March 2020

1 reference

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6 March 2020

1 reference

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6 March 2020

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