Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death (Q39134944)

9 September 2017

title

Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death (English)

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9 September 2017

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12

Andreas von Deimling

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David Capper

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object named as

David Capper

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9 September 2017

author name string

Isabelle Vanessa Mohrenz

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Patrick Antonietti

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Stefan Pusch

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Jörg Balss

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Sophia Voigt

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Susanne Weissert

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Alicia Mukrowsky

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Jan Frank

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Christian Senft

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Volker Seifert

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Donat Kögel

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publication date

1 November 2013

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9 September 2017

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9 September 2017

volume

18

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issue

11

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page(s)

1416-1425

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Genetic profile of astrocytic and oligodendroglial gliomas

9 September 2017

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication

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IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

21 January 2018

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Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas.

21 January 2018

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IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group

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Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas

21 January 2018

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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

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D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

21 January 2018

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

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Cellular defense against UVB-induced phototoxicity by cytosolic NADP(+)-dependent isocitrate dehydrogenase

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Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism

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Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells

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The prognostic IDH1( R132 ) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma

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Monoclonal antibody specific for IDH1 R132H mutation

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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

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Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.

21 January 2018

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Glutamine addiction: a new therapeutic target in cancer

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

21 January 2018

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Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism

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21 January 2018

Identifiers

DOI

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9 September 2017

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