Intracellular itinerary of internalised β-secretase, BACE1, and its potential impact on β-amyloid peptide biogenesis. (Q39138637)

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3 March 2020

title

Intracellular itinerary of internalised β-secretase, BACE1, and its potential impact on β-amyloid peptide biogenesis (English)

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3 March 2020

5

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Paul A. Gleeson

6

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3 March 2020

author name string

Pei Zhi Cheryl Chia

1

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3 March 2020

Wei Hong Toh

2

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3 March 2020

Robyn Sharples

3

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3 March 2020

Isabelle Gasnereau

4

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publication date

8 July 2013

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3 March 2020

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volume

14

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issue

9

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3 March 2020

page(s)

997-1013

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

3 March 2020

cites work

1 reference

Intracellular APP processing and A beta production in Alzheimer disease

21 January 2018

1 reference

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

21 January 2018

1 reference

Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells

21 January 2018

1 reference

Beta-amyloid precursor protein cleavage by a membrane-bound protease

21 January 2018

1 reference

The Alzheimer's disease beta-secretase enzyme, BACE1.

21 January 2018

1 reference

BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis

21 January 2018

1 reference

Amyloid precursor protein trafficking, processing, and function

21 January 2018

1 reference

Neurotoxic traffic: uncovering the mechanics of amyloid production in Alzheimer's disease

21 January 2018

1 reference

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

21 January 2018

1 reference

Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.

21 January 2018

1 reference

Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans-Golgi network

21 January 2018

1 reference

Model-guided microarray implicates the retromer complex in Alzheimer's disease

21 January 2018

1 reference

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation

21 January 2018

1 reference

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

21 January 2018

1 reference

Maturation and pro-peptide cleavage of beta-secretase

21 January 2018

1 reference

Processing of beta-secretase by furin and other members of the proprotein convertase family

21 January 2018

1 reference

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

21 January 2018

1 reference

GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

21 January 2018

1 reference

GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network

21 January 2018

1 reference

BACE is degraded via the lysosomal pathway

21 January 2018

1 reference

Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway

21 January 2018

1 reference

Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated

21 January 2018

1 reference

Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

21 January 2018

1 reference

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

A transgenic approach for RNA interference-based genetic screening in mice

21 January 2018

1 reference

21 January 2018

1 reference

Rab11 regulates the compartmentalization of early endosomes required for efficient transport from early endosomes to the trans-golgi network

21 January 2018

1 reference

Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin

21 January 2018

1 reference

Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference

21 January 2018

1 reference

Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition

21 January 2018

1 reference

TGN38 and its orthologues: roles in post-TGN vesicle formation and maintenance of TGN morphology

21 January 2018

1 reference

Rab9-dependent retrograde transport and endosomal sorting of the endopeptidase furin.

21 January 2018

1 reference

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

21 January 2018

1 reference

The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta).

21 January 2018

1 reference

Pitstop 2 is a potent inhibitor of clathrin-independent endocytosis

21 January 2018

1 reference

A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex

21 January 2018

1 reference

21 January 2018

1 reference

Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin

21 January 2018

1 reference

Evolving endosomes: how many varieties and why?

21 January 2018

1 reference

Pathways and mechanisms of endocytic recycling

21 January 2018

1 reference

Phosphorylation regulates intracellular trafficking of beta-secretase

21 January 2018

1 reference

SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors

21 January 2018

1 reference

Retromer guides STxB and CD8-M6PR from early to recycling endosomes, EHD1 guides STxB from recycling endosome to Golgi

21 January 2018

1 reference

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

21 January 2018

1 reference

Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA.

21 January 2018

1 reference

The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments

21 January 2018

1 reference

Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein.

21 January 2018

1 reference

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

21 January 2018

1 reference

Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis

21 January 2018

1 reference

Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

21 January 2018

1 reference

Retromer disruption promotes amyloidogenic APP processing

21 January 2018

1 reference

Sec15 is an effector for the Rab11 GTPase in mammalian cells

21 January 2018

1 reference

Multicolour imaging of post-Golgi sorting and trafficking in live cells

21 January 2018

1 reference

Differential PI 3-kinase dependence of early and late phases of recycling of the internalized AT1 angiotensin receptor

21 January 2018

1 reference

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

21 January 2018

1 reference

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay

21 January 2018

1 reference

The golgin GCC88 is required for efficient retrograde transport of cargo from the early endosomes to the trans-Golgi network

21 January 2018

1 reference

Clathrin-mediated endocytosis in AP-2-depleted cells

21 January 2018

1 reference

An ARF6/Rab35 GTPase cascade for endocytic recycling and successful cytokinesis.

21 January 2018

1 reference

Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization

21 January 2018

1 reference

Automated organelle-based colocalization in whole-cell imaging

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/TRA.12088

1 reference

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release_xnd5p4cynzhfzajdgbmwqeodim

3 March 2020

Fatcat ID

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Fatcat

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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