Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease (Q39140524)

9 September 2017

Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease (English)

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metabolic dysfunction–associated steatotic liver disease

9 September 2017

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Tomasz Kostrzewski

1

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9 September 2017

Terri Cornforth

2

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9 September 2017

Sophie A Snow

3

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9 September 2017

Larissa Ouro-Gnao

4

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9 September 2017

Cliff Rowe

5

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9 September 2017

Emma M Large

6

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9 September 2017

David J Hughes

7

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9 September 2017

language of work or name

English

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publication date

1 January 2017

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World Journal of Gastroenterology

9 September 2017

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9 September 2017

23

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9 September 2017

2

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9 September 2017

204-215

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describes a project that uses

9 September 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5236500/fullTextXML

inferred from PubMed Central ID database lookup

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Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes

10 September 2017

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Role of Macrophage Migration Inhibitory Factor in Obesity, Insulin Resistance, Type 2 Diabetes, and Associated Hepatic Co-Morbidities: A Comprehensive Review of Human and Rodent Studies

10 September 2017

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Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research

10 September 2017

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Nonalcoholic Steatohepatitis: A Search for Factual Animal Models

10 September 2017

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Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor

10 September 2017

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The application of engineered liver tissues for novel drug discovery

10 September 2017

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Organs-on-chips at the frontiers of drug discovery

10 September 2017

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Nonalcoholic fatty liver disease: new treatments

10 September 2017

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A concise review of non-alcoholic fatty liver disease

10 September 2017

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Focus on emerging drugs for the treatment of patients with non-alcoholic fatty liver disease

10 September 2017

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Noninvasive biomarkers in non-alcoholic fatty liver disease: current status and a glimpse of the future

10 September 2017

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Bioreactor technologies to support liver function in vitro.

10 September 2017

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Association between Serum Albumin, Insulin Resistance, and Incident Diabetes in Nondiabetic Subjects

10 September 2017

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Metformin prevents hepatic steatosis by regulating the expression of adipose differentiation-related protein

10 September 2017

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Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease

10 September 2017

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10 September 2017

The genetics of NAFLD.

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Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes

10 September 2017

1 reference

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Long-term culture and coculture of primary rat and human hepatocytes

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Effect of intracellular lipid accumulation in a new model of non-alcoholic fatty liver disease

10 September 2017

1 reference

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Role of cytokines and chemokines in non-alcoholic fatty liver disease

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

From 3D cell culture to organs-on-chips

10 September 2017

1 reference

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A novel 3D liver organoid system for elucidation of hepatic glucose metabolism

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

In vitro models for the study of non-alcoholic fatty liver disease.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Dissociation between intrahepatic triglyceride content and insulin resistance in familial hypobetalipoproteinemia

10 September 2017

1 reference

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Quantification and mechanisms of oleic acid-induced steatosis in HepG2 cells.

10 September 2017

1 reference

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Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndrome

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Perfused multiwell plate for 3D liver tissue engineering

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Liver tissue engineering in the evaluation of drug safety

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Non alcoholic fatty liver disease and metabolic syndrome.

10 September 2017

1 reference

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Cell lines: a tool for in vitro drug metabolism studies

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

PPAR gamma and human metabolic disease

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Effects of the PPARgamma agonist pioglitazone on lipoprotein metabolism in patients with type 2 diabetes mellitus

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Molecular mediators of hepatic steatosis and liver injury

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Metformin reverses fatty liver disease in obese, leptin-deficient mice

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Pioglitazone stimulates apolipoprotein A-I production without affecting HDL removal in HepG2 cells: involvement of PPAR-alpha

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

A human hepatocellular in vitro model to investigate steatosis.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Liv.52 up-regulates cellular antioxidants and increase glucose uptake to circumvent oleic acid induced hepatic steatosis in HepG2 cells.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Predictive factors for nonalcoholic steatohepatitis (NASH) in patients with nonalcoholic fatty liver disease (NAFLD).

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Macrophage migration inhibitory factor expression and MIF gene -173 G/C polymorphism in nonalcoholic fatty liver disease

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

A lipidomic analysis of nonalcoholic fatty liver disease.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5236500

Association between serum albumin, carotid atherosclerosis, and metabolic syndrome in Japanese individuals

21 August 2018

1 reference

12 December 2020

Use of three-dimensional spheroids of hepatocyte-derived reporter cells to study the effects of intracellular fat accumulation and subsequent cytokine exposure

1 reference

12 December 2020

Potential Impact of Steatosis on Cytochrome P450 Enzymes of Human Hepatocytes Isolated from Fatty Liver Grafts

1 reference

12 December 2020

Effects of steatosis on drug-metabolizing capability of primary human hepatocytes

1 reference

12 December 2020

Identifiers

DOI

10.3748/WJG.V23.I2.204

1 reference

9 September 2017

1 reference

9 September 2017

PubMed publication ID

28127194

1 reference