Monoclonal antibodies toward different Tn-amino acid backbones display distinct recognition patterns on human cancer cells. Implications for effective immuno-targeting of cancer. (Q39162905)

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scientific article published on 21 April 2013

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English	Monoclonal antibodies toward different Tn-amino acid backbones display distinct recognition patterns on human cancer cells. Implications for effective immuno-targeting of cancer.	scientific article published on 21 April 2013

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29 February 2020

Monoclonal antibodies toward different Tn-amino acid backbones display distinct recognition patterns on human cancer cells. Implications for effective immuno-targeting of cancer (English)

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29 February 2020

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Mariela Bollati-Fogolín

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29 February 2020

author name string

Daniel Mazal

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29 February 2020

Richard Lo-Man

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Sylvie Bay

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Otto Pritsch

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Edith Dériaud

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Christelle Ganneau

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Andrea Medeiros

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Luis Ubillos

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Gonzalo Obal

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Nora Berois

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29 February 2020

Claude Leclerc

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Eduardo Osinaga

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publication date

21 April 2013

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Cancer Immunology, Immunotherapy

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1107-1122

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29 February 2020

https://scigraph.springernature.com/pub.10.1007/s00262-013-1425-7

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MUC1 and the MUCs: a family of human mucins with impact in cancer biology

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Two opposing roles of O-glycans in tumor metastasis

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All in the family: the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases

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Mucin-type O-glycans in human colon and breast cancer: glycodynamics and functions

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A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase

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Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen

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A mutant chaperone converts a wild-type protein into a tumor-specific antigen

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Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc

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Expression of CD175 (Tn), CD175s (sialosyl-Tn) and CD176 (Thomsen-Friedenreich antigen) on malignant human hematopoietic cells

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Mucin associated Tn and sialosyl-Tn antigen expression in colorectal polyps

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Tn antigen is a pre-cancerous biomarker in breast tissue and serum in n-nitrosomethylurea-induced rat mammary carcinogenesis.

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Immunoreactive T and Tn epitopes in cancer diagnosis, prognosis, and immunotherapy

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A fully synthetic therapeutic vaccine candidate targeting carcinoma-associated Tn carbohydrate antigen induces tumor-specific antibodies in nonhuman primates

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Mucin-type O-glycosylation and its potential use in drug and vaccine development

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The Tn antigen-structural simplicity and biological complexity

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21 January 2018

Expression of Tn, sialosyl Tn, and T antigens in human pancreas

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Effect of glycosylation on MUC1 humoral immune recognition: NMR studies of MUC1 glycopeptide-antibody interactions

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Epitopic structure of Tn glycophorin A for an anti-Tn antibody (MLS 128).

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Anti-tumor immunity provided by a synthetic multiple antigenic glycopeptide displaying a tri-Tn glycotope

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Tissue microarrays for high-throughput molecular profiling of tumor specimens

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Validation of tissue microarray technology in breast carcinoma

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Resolving conflicting data on expression of the Tn antigen and implications for clinical trials with cancer vaccines

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Serine versus threonine glycosylation: the methyl group causes a drastic alteration on the carbohydrate orientation and on the surrounding water shell

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The nature and sequence of the amino acid aglycone strongly modulates the conformation and dynamics effects of Tn antigen's clusters

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21 January 2018

Analysis of Tn antigenicity with a panel of new IgM and IgG1 monoclonal antibodies raised against leukemic cells.

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21 January 2018

Database analysis of O-glycosylation sites in proteins

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The acceptor specificity of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases

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21 January 2018

Postoperative change of anti-Thomsen-Friedenreich and Tn IgG level: the follow-up study of gastrointestinal cancer patients

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Microarrays with varying carbohydrate density reveal distinct subpopulations of serum antibodies

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21 January 2018

Immunohistochemical study of the expression of MUC5AC and MUC6 in breast carcinomas and adjacent breast tissues

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Detection of bone marrow-disseminated breast cancer cells using an RT-PCR assay of MUC5B mRNA.

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MUC6 expression in breast tissues and cultured cells: abnormal expression in tumors and regulation by steroid hormones.

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Mucins and mucin binding proteins in colorectal cancer

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A new murine IgG1 anti-Tn monoclonal antibody with in vivo anti-tumor activity

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Mouse-human chimeric anti-Tn IgG1 induced anti-tumor activity against Jurkat cells in vitro and in vivo

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Antibody-dependent cell cytotoxicity synapses form in mice during tumor-specific antibody immunotherapy

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A newly generated functional antibody identifies Tn antigen as a novel determinant in the cancer cell-lymphatic endothelium interaction

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Biochemical and functional characterization of the Tn-specific lectin from Salvia sclarea seeds

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Analysis of the fine specificity of Tn-binding proteins using synthetic glycopeptide epitopes and a biosensor based on surface plasmon resonance spectroscopy

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