Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer. (Q39186300)

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24 February 2020

title

Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer (English)

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24 February 2020

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15

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24 February 2020

Sampurna Chatterjee

1

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24 February 2020

Lydia Meder

10

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24 February 2020

Daniel Rauh

11

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24 February 2020

author name string

Lukas C Heukamp

2

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24 February 2020

Maike Siobal

3

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Jakob Schöttle

4

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24 February 2020

Caroline Wieczorek

5

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24 February 2020

Martin Peifer

6

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24 February 2020

Davide Frasca

7

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Mirjam Koker

8

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Katharina König

9

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Reinhard Buettner

12

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24 February 2020

Jürgen Wolf

13

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Rolf A Brekken

14

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24 February 2020

Gerhard Christofori

16

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24 February 2020

Roman K Thomas

17

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24 February 2020

Roland T Ullrich

18

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language of work or name

English

0 references

publication date

1 April 2013

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Journal of Clinical Investigation

24 February 2020

published in

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24 February 2020

volume

123

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24 February 2020

issue

4

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24 February 2020

page(s)

1732-1740

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Combined MEK and VEGFR inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis

24 February 2020

cites work

1 reference

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Increased VEGFR-2 gene copy is associated with chemoresistance and shorter survival in patients with non-small-cell lung carcinoma who receive adjuvant chemotherapy

10 September 2017

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

10 September 2017

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VEGFR-2 expression in carcinoid cancer cells and its role in tumor growth and metastasis

10 September 2017

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AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

10 September 2017

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The angiogenic switch in carcinogenesis

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Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions

10 September 2017

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Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1

10 September 2017

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Vascular endothelial growth factor, FLT-1, and FLK-1 analysis in a pancreatic cancer tissue microarray

10 September 2017

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

10 September 2017

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Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?

10 September 2017

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Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

10 September 2017

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Positron emission tomographic imaging of angiogenesis and vascular function.

10 September 2017

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Mechanisms of angiogenesis and arteriogenesis

10 September 2017

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Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)

10 September 2017

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Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development

10 September 2017

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Glioma proliferation as assessed by 3'-fluoro-3'-deoxy-L-thymidine positron emission tomography in patients with newly diagnosed high-grade glioma

14 September 2017

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14 September 2017

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Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors.

15 June 2018

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TSC2 regulates VEGF through mTOR-dependent and -independent pathways

21 August 2018

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ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration.

21 August 2018

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21 August 2018

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21 August 2018

Identifiers

DOI

10.1172/JCI65385

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24 February 2020

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24 February 2020

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