Combination of a novel HDAC inhibitor OBP-801/YM753 and a PI3K inhibitor LY294002 synergistically induces apoptosis in human endometrial carcinoma cells due to increase of Bim with accumulation of ROS. (Q39195722)

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scientific article published on 9 February 2013

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English	Combination of a novel HDAC inhibitor OBP-801/YM753 and a PI3K inhibitor LY294002 synergistically induces apoptosis in human endometrial carcinoma cells due to increase of Bim with accumulation of ROS.	scientific article published on 9 February 2013

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scholarly article

1 reference

Europe PubMed Central

9 September 2017

Combination of a novel HDAC inhibitor OBP-801/YM753 and a PI3K inhibitor LY294002 synergistically induces apoptosis in human endometrial carcinoma cells due to increase of Bim with accumulation of ROS. (English)

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Europe PubMed Central

9 September 2017

endometrial carcinoma

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based on heuristic

inferred from title

author name string

Takashi Yoshioka

1

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Europe PubMed Central

9 September 2017

Shingo Yogosawa

2

1 reference

Europe PubMed Central

9 September 2017

Takeshi Yamada

3

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Europe PubMed Central

9 September 2017

Jo Kitawaki

4

1 reference

Europe PubMed Central

9 September 2017

Toshiyuki Sakai

5

1 reference

Europe PubMed Central

9 September 2017

language of work or name

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publication date

9 February 2013

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Europe PubMed Central

9 September 2017

Gynecologic Oncology

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Europe PubMed Central

9 September 2017

129

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Europe PubMed Central

9 September 2017

425-432

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Europe PubMed Central

9 September 2017

2

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Europe PubMed Central

9 September 2017

Genetics of endometrial cancers

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2013.02.008

7 January 2021

Novel molecular profiles of endometrial cancer-new light through old windows.

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2013.02.008

7 January 2021

Endometrial cancer

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2013.02.008

7 January 2021

Endometrial carcinoma

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https://api.crossref.org/works/10.1016%2FJ.YGYNO.2013.02.008

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Markers for individualised therapy in endometrial carcinoma

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Emerging therapeutic targets in endometrial cancer

1 reference

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Mechanism of apicidin-induced cell cycle arrest and apoptosis in Ishikawa human endometrial cancer cells.

1 reference

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7 January 2021

Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.YGYNO.2013.02.008

7 January 2021

Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells

1 reference

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7 January 2021

High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma

1 reference

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Stromal cell-derived factor 1alpha stimulates human endometrial carcinoma cell growth through the activation of both extracellular signal-regulated kinase 1/2 and Akt.

1 reference

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Inhibiting the PI3K/Akt pathway reversed progestin resistance in endometrial cancer

1 reference

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Blockade of the ERK or PI3K-Akt signaling pathway enhances the cytotoxicity of histone deacetylase inhibitors in tumor cells resistant to gefitinib or imatinib

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Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition

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Malignant mesothelioma cells are rapidly sensitized to TRAIL-induced apoptosis by low-dose anisomycin via Bim.

1 reference

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7 January 2021

Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim.

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SAHA induces apoptosis in hepatoma cells and synergistically interacts with the proteasome inhibitor Bortezomib

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The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways

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Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway

1 reference

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7 January 2021

Skin mild hypoxia enhances killing of UVB-damaged keratinocytes through reactive oxygen species-mediated apoptosis requiring Noxa and Bim.

1 reference

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7 January 2021

Molecular mechanisms involved in the adaptive response to cadmium-induced apoptosis in human myelomonocytic lymphoma U937 cells

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Dual regulation of hepatocyte apoptosis by reactive oxygen species: Increases in transcriptional expression and decreases in proteasomal degradation of BimEL.

1 reference

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7 January 2021

FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3.

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Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2.

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The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways

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Endometrial Glandular Dysplasia with Frequent p53 Gene Mutation: A Genetic Evidence Supporting Its Precancer Nature for Endometrial Serous Carcinoma

1 reference

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Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis.

1 reference

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7 January 2021

PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters

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p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y

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Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells

1 reference

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7 January 2021

Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter

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7 January 2021

p15INK4b in HDAC inhibitor‐induced growth arrest

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Trichostatin A activates p18INK4c gene: differential activation and cooperation with p19INK4d gene

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Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line

1 reference

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Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites

1 reference

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7 January 2021

Eupatilin, a dietary flavonoid, induces G2/M cell cycle arrest in human endometrial cancer cells

1 reference

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Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines

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7 January 2021

Identifiers

10.1016/J.YGYNO.2013.02.008

1 reference

Europe PubMed Central

9 September 2017

1 reference

Europe PubMed Central

9 September 2017

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