In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing (Q39206459)

10 September 2017

In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing (English)

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10 September 2017

Ludwig Christian Hinske

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object named as

Ludwig C Hinske

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10 September 2017

Simone Kreth

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10 September 2017

Elisabeth Limbeck

2

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10 September 2017

Stefanie V Schütz

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10 September 2017

Niklas Thon

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10 September 2017

Kai Hoefig

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10 September 2017

Rupert Egensperger

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10 September 2017

Friedrich W Kreth

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10 September 2017

23 January 2013

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10 September 2017

Acta Neuropathologica

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10 September 2017

125

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10 September 2017

5

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10 September 2017

671-681

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https://scigraph.springernature.com/pub.10.1007/s00401-013-1081-1

10 September 2017

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cites work

MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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Mechanisms and consequences of alternative polyadenylation

21 January 2018

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Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas

21 January 2018

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MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

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AU-rich element-mediated mRNA decay can occur independently of the miRNA machinery in mouse embryonic fibroblasts and Drosophila S2-cells

21 January 2018

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O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells

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Bioinformatic identification of candidate cis-regulatory elements involved in human mRNA polyadenylation

21 January 2018

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Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development.

21 January 2018

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Reprogramming of 3' untranslated regions of mRNAs by alternative polyadenylation in generation of pluripotent stem cells from different cell types

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Human MicroRNA targets

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MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents

21 January 2018

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Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts

21 January 2018

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Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts

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Identification of valid endogenous control genes for determining gene expression in human glioma

21 January 2018

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O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation

21 January 2018

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Epigenetics in human gliomas

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Novel mechanism whereby nuclear factor kappaB mediates DNA damage repair through regulation of O(6)-methylguanine-DNA-methyltransferase

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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

21 January 2018

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MicroRNA expression profiles classify human cancers

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A distinct region of the MGMT CpG island critical for transcriptional regulation is preferentially methylated in glioblastoma cells and xenografts.

21 January 2018

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Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells

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Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites

21 January 2018

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Global changes in processing of mRNA 3' untranslated regions characterize clinically distinct cancer subtypes

21 January 2018

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Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution

21 January 2018

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Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

21 January 2018

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Transfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agents

21 January 2018

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21 January 2018

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The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island.

21 January 2018

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10.1007/S00401-013-1081-1

21 January 2018

Identifiers

DOI

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release_fu4ry674abfi5feojk7x2feoly

10 September 2017

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