Integrative molecular and functional profiling of ERBB2-amplified breast cancers identifies new genetic dependencies (Q39207741)

10 September 2017

title

Integrative molecular and functional profiling of ERBB2-amplified breast cancers identifies new genetic dependencies (English)

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10 September 2017

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R Natrajan

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Alan Ashworth

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object named as

A Ashworth

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10 September 2017

3

A Mackay

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K-K Shiu

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D Wetterskog

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M Lambros

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D Sims

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I Bajrami

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R Brough

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J Frankum

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R Sharpe

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C Marchio

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H Horlings

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F Reyal

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10 September 2017

M van der Vijver

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N Turner

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J S Reis-Filho

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10 September 2017

language of work or name

English

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publication date

21 January 2013

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10 September 2017

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10 September 2017

volume

33

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10 September 2017

issue

5

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10 September 2017

page(s)

619-631

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

10 September 2017

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An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers

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The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma

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Identification of HTF (HER2 transcription factor) as an AP-2 (activator protein-2) transcription factor and contribution of the HTF binding site to ERBB2 gene overexpression

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AP-2gamma promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene

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Distal ERBB2 promoter fragment displays specific transcriptional and nuclear binding activities in ERBB2 overexpressing breast cancer cells

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31 March 2020

Identifiers

DOI

10.1038/ONC.2012.625

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Dimensions Publication ID

10 September 2017

1012404890

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Fatcat ID

release_6o2xzhuderc57bhyrtnwvv4n7m

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1 reference