Sustained inhibition of deacetylases is required for the antitumor activity of the histone deactylase inhibitors panobinostat and vorinostat in models of colorectal cancer. (Q39214195)

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English	Sustained inhibition of deacetylases is required for the antitumor activity of the histone deactylase inhibitors panobinostat and vorinostat in models of colorectal cancer.	scientific article

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21 February 2020

Sustained inhibition of deacetylases is required for the antitumor activity of the histone deactylase inhibitors panobinostat and vorinostat in models of colorectal cancer (English)

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21 February 2020

colorectal cancer

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Melissa J LaBonte

2

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21 February 2020

Heinz-Josef Lenz

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Heinz-Josef Lenz

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21 February 2020

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Peter M Wilson

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21 February 2020

Shelby C Martin

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21 February 2020

Stephanie T Kuwahara

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21 February 2020

Anthony El-Khoueiry

5

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21 February 2020

Robert D Ladner

7

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21 February 2020

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9 January 2013

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21 February 2020

Investigational New Drugs

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21 February 2020

31

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21 February 2020

4

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21 February 2020

845-857

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21 February 2020

Histone acetylation and transcriptional regulatory mechanisms

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

HDAC inhibitors: clinical update and mechanism-based potential.

1 reference

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21 January 2018

Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.

1 reference

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21 January 2018

Acetylation and deacetylation of non-histone proteins

1 reference

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21 January 2018

HDAC6 is a microtubule-associated deacetylase

1 reference

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21 January 2018

The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines.

1 reference

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21 January 2018

Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment

1 reference

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21 January 2018

Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T-cell lymphoma

1 reference

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21 January 2018

The role of histone deacetylases in prostate cancer.

1 reference

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21 January 2018

Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression

1 reference

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21 January 2018

HDAC4 promotes growth of colon cancer cells via repression of p21.

1 reference

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21 January 2018

Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines

1 reference

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21 January 2018

DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

Histone deacetylases and cancer: causes and therapies

1 reference

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21 January 2018

Clinical development of histone deacetylase inhibitors as anticancer agents

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

Development of vorinostat: current applications and future perspectives for cancer therapy

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

Development of the pan-DAC inhibitor panobinostat (LBH589): successes and challenges

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

Anticancer activities of histone deacetylase inhibitors

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

Histone deacetylase inhibitors suppress thymidylate synthase gene expression and synergize with the fluoropyrimidines in colon cancer cells.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

A phase I, pharmacokinetic and pharmacodynamic study on vorinostat in combination with 5-fluorouracil, leucovorin, and oxaliplatin in patients with refractory colorectal cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

A phase I/II trial of vorinostat in combination with 5-fluorouracil in patients with metastatic colorectal cancer who previously failed 5-FU-based chemotherapy

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

A phase I, pharmacokinetic, and pharmacodynamic study of two schedules of vorinostat in combination with 5-fluorouracil and leucovorin in patients with refractory solid tumors

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

Modulation of thymidilate synthase and p53 expression by HDAC inhibitor vorinostat resulted in synergistic antitumor effect in combination with 5FU or raltitrexed

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

A phase I study of oral panobinostat alone and in combination with docetaxel in patients with castration-resistant prostate cancer.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

The effect of food on the bioavailability of panobinostat, an orally active pan-histone deacetylase inhibitor, in patients with advanced cancer

1 reference

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21 January 2018

Activity of deacetylase inhibitor panobinostat (LBH589) in cutaneous T-cell lymphoma models: Defining molecular mechanisms of resistance

1 reference

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21 January 2018

Preclinical evaluation of dual PI3K-mTOR inhibitors and histone deacetylase inhibitors in head and neck squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

Combination therapy for hepatocellular carcinoma: additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

Pretreatment with anti-oxidants sensitizes oxidatively stressed human cancer cells to growth inhibitory effect of suberoylanilide hydroxamic acid (SAHA).

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

Co-treatment with vorinostat synergistically enhances activity of Aurora kinase inhibitor against human breast cancer cells.

1 reference

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21 January 2018

Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage

1 reference

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21 January 2018

Novel opportunities for thymidylate metabolism as a therapeutic target.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase

1 reference

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21 January 2018

Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase.

1 reference

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21 January 2018

Histone deacetylase inhibitors: multifunctional anticancer agents.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9914-7

21 January 2018

SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer.

1 reference

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21 January 2018

Phase I clinical, pharmacokinetic and pharmacodynamic study of SB939, an oral histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumours

1 reference

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21 January 2018

The role of oxidative stress in apoptosis induced by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in human colon adenocarcinoma HT-29 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23299388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23299388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase inhibitors induce mitotic slippage

1 reference

https://pubmed.ncbi.nlm.nih.gov/23299388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A liquid chromatography-electrospray ionization tandem mass spectrometric assay for quantitation of the histone deacetylase inhibitor, vorinostat (suberoylanilide hydroxamicacid, SAHA), and its metabolites in human serum

1 reference

https://pubmed.ncbi.nlm.nih.gov/23299388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized phase II study of two doses of vorinostat in combination with 5-FU/LV in patients with refractory colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23299388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low-dose combinations of LBH589 and TRAIL can overcome TRAIL-resistance in colon cancer cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23299388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10637-012-9914-7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23299388%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23299388%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

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