Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells (Q39235972)

10 September 2017

title

Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells (English)

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10 September 2017

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Chenglin Li

1

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10 September 2017

Qi Qi

2

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10 September 2017

Na Lu

3

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10 September 2017

Qinsheng Dai

4

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10 September 2017

Fanni Li

5

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10 September 2017

Xiaotang Wang

6

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10 September 2017

Qidong You

7

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10 September 2017

Qinglong Guo

8

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10 September 2017

publication date

30 October 2012

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Biochemistry and Cell Biology

10 September 2017

published in

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10 September 2017

volume

90

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10 September 2017

issue

6

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10 September 2017

page(s)

718-730

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Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells

10 September 2017

cites work

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Detection of apoptosis induced by new type gosling viral enteritis virus in vitro through fluorescein annexin V-FITC/PI double labeling

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Hispolon induces apoptosis in human gastric cancer cells through a ROS-mediated mitochondrial pathway

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Reactive oxygen species-mitochondria pathway involved in LYG-202-induced apoptosis in human hepatocellular carcinoma HepG(2) cells.

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Preclinical and clinical studies of novel breast cancer drugs targeting molecules involved in protein kinase C signaling, the putative metastasis-suppressor gene Cap43 and the Y-box binding protein-1.

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Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells

21 January 2018

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Gambogic acid induced tumor cell apoptosis by T lymphocyte activation in H22 transplanted mice

21 January 2018

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Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells

21 January 2018

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The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells.

21 January 2018

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21 January 2018

Cancer statistics, 2009

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A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid

21 January 2018

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Gambogic acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells

21 January 2018

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Gambogic acid inhibits tumor cell adhesion by suppressing integrin β1 and membrane lipid rafts-associated integrin signaling pathway

21 January 2018

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The constitution of gambogic acid and its isomerization. 4. Chemistry of gum-resin

21 January 2018

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Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823

21 January 2018

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Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants

21 January 2018

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Gambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1.

21 January 2018

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Apoptosis--molecular mechanisms and biomedical implications

21 January 2018

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Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells

21 January 2018

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Gambogic acid covalently modifies IkappaB kinase-beta subunit to mediate suppression of lipopolysaccharide-induced activation of NF-kappaB in macrophages

21 January 2018

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Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway

21 January 2018

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Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release

21 January 2018

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Role of the Akt/mTOR survival pathway in cisplatin resistance in ovarian cancer cells

21 January 2018

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Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis

21 January 2018

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Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cells

21 January 2018

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Studies on the toxicity of gambogic acid in rats

21 January 2018

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Gambogic acid inhibits the catalytic activity of human topoisomerase IIalpha by binding to its ATPase domain.

21 January 2018

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Mitochondrial dysfunction in CD47-mediated caspase-independent cell death: ROS production in the absence of cytochrome c and AIF release

21 January 2018

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Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP.

21 January 2018

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Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells

21 January 2018

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Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes

21 January 2018

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Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling.

21 January 2018

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Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cells

21 January 2018

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Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells

21 January 2018

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Specific and slow inhibition of the kir2.1 K+ channel by gambogic acid

21 January 2018

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Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins

21 January 2018

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Reactive oxygen special (ROS), troublemakers between nuclear factor-kB (NF-kB) and c-Jun NH2-terminal kinase (JNK)

21 January 2018

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Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay

21 January 2018

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Inhibition of alpha(4) integrin mediated adhesion was involved in the reduction of B16-F10 melanoma cells lung colonization in C57BL/6 mice treated with gambogic acid

21 January 2018

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Posttranscriptional regulation of the telomerase hTERT by gambogic acid in human gastric carcinoma 823 cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/O2012-030

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release_3pb6vceywjdp7b4yjc2mj6qupm

10 September 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/3pb6vceywjdp7b4yjc2mj6qupm

mapped directly with Wikidata item

24 November 2022

based on heuristic

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