Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. (Q39250861)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17822548%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

title

Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau (English)

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6 January 2020

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2

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6 January 2020

author name string

Ismael Santa-Maria

1

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6 January 2020

Joaquín Del Rio

3

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6 January 2020

Francisco J Moreno

4

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6 January 2020

Jesús Avila

5

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6 January 2020

publication date

6 September 2007

1 reference

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Molecular Neurodegeneration

6 January 2020

published in

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6 January 2020

volume

2

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6 January 2020

page(s)

17

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https://scigraph.springernature.com/pub.10.1186/1750-1326-2-17

6 January 2020

exact match

0 references

cites work

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The sulfate moieties of glycosaminoglycans are critical for the enhancement of beta-amyloid protein fibril formation

10 September 2017

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10 September 2017

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Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly

10 September 2017

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Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

10 September 2017

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Chondroitin sulfate proteoglycans are associated with the lesions of Alzheimer's disease

10 September 2017

1 reference

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An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain

10 September 2017

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Altered microtubule organization in small-calibre axons of mice lacking tau protein

10 September 2017

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A taxol-dependent procedure for the isolation of microtubules and microtubule-associated proteins (MAPs).

10 September 2017

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

10 September 2017

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Cationic dyes reveal proteoglycans structurally integrated within the characteristic lesions of Alzheimer's disease

10 September 2017

1 reference

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Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome

10 September 2017

1 reference

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Proteoglycans: structures and interactions

10 September 2017

1 reference

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Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones

10 September 2017

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Calcium, free radicals, and excitotoxic neuronal death in primary cell culture

10 September 2017

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The role of heparan sulfate proteoglycans in the pathogenesis of Alzheimer's disease

14 September 2017

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Regulation of microtubule dynamics by microtubule-associated protein expression and phosphorylation during neuronal development.

25 September 2017

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Cortical areas abundant in extracellular matrix chondroitin sulphate proteoglycans are less affected by cytoskeletal changes in Alzheimer's disease.

25 September 2017

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Role of glycosaminoglycans in determining the helicity of paired helical filaments

15 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048960

Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease

15 June 2018

1 reference

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Effects of sulfate ions on Alzheimer beta/A4 peptide assemblies: implications for amyloid fibril-proteoglycan interactions

15 June 2018

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15 June 2018

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Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.

15 June 2018

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Characteristics of the binding of thioflavin S to tau paired helical filaments.

21 August 2018

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Tau associates with actin in differentiating PC12 cells.

21 August 2018

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Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis.

21 August 2018

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Peripheral treatment with enoxaparin, a low molecular weight heparin, reduces plaques and beta-amyloid accumulation in a mouse model of Alzheimer's disease.

21 August 2018

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21 August 2018

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In vitro assembly of tau protein: mapping the regions involved in filament formation

21 August 2018

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C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease.

21 August 2018

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Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.

21 August 2018

1 reference

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Heparan sulfate and chondroitin sulfate glycosaminoglycan attenuate beta-amyloid(25-35) induced neurodegeneration in cultured hippocampal neurons.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048960

Assembly of Alzheimer-like filaments from full-length tau protein.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048960

Proteoglycan-mediated inhibition of A beta proteolysis. A potential cause of senile plaque accumulation.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048960

Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17822548

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effect of amino-acid substitutions on Alzheimer's amyloid-beta peptide-glycosaminoglycan interactions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17822548

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1750-1326-2-17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17822548%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17822548%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1 reference