Altered arachidonic acid metabolism via COX-1 and COX-2 contributes to the endothelial dysfunction of penile arteries from obese Zucker rats. (Q39253285)

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English	Altered arachidonic acid metabolism via COX-1 and COX-2 contributes to the endothelial dysfunction of penile arteries from obese Zucker rats.	scientific article

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16 January 2020

Altered arachidonic acid metabolism via COX-1 and COX-2 contributes to the endothelial dysfunction of penile arteries from obese Zucker rats (English)

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16 January 2020

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Cristina Contreras

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16 January 2020

Mercedes Salaices

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A Sánchez

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N Villalba

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P Martínez

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A C Martínez

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16 January 2020

A Bríones

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A García-Sacristán

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M Hernández

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15 January 2010

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British Journal of Pharmacology

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604-616

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16 January 2020

Endothelial dysfunction and vascular disease

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10 September 2017

Attenuated PGI2 synthesis in obese Zucker rats

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10 September 2017

Increased vascular thromboxane generation impairs dilation of skeletal muscle arterioles of obese Zucker rats with reduced oxygen tension.

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Physiological regulation of penile arteries and veins

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Double-label expression studies of prostacyclin synthase, thromboxane synthase and COX isoforms in normal aortic endothelium

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Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation

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Erectile dysfunction as an early sign of cardiovascular disease

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Endothelial and erectile dysfunction, diabetes mellitus, and the metabolic syndrome: common pathways and treatments?

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10 September 2017

Effect of sildenafil on non-adrenergic non-cholinergic neurotransmission in bovine penile small arteries

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10 September 2017

Alteration of flow-induced dilatation in mesenteric resistance arteries of L-NAME treated rats and its partial association with induction of cyclo-oxygenase-2.

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Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear str

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Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain

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10 September 2017

Oxidative stress and COX cause hyper-responsiveness in vascular smooth muscle of the femoral artery from diabetic rats.

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14 September 2017

Oxygen-derived free radicals mediate endothelium-dependent contractions to acetylcholine in aortas from spontaneously hypertensive rats

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Contribution of K+ channels and ouabain-sensitive mechanisms to the endothelium-dependent relaxations of horse penile small arteries.

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Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence

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17 June 2018

Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues

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17 June 2018

Endothelium-derived nitric oxide and cyclooxygenase products modulate corpus cavernosum smooth muscle tone

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17 June 2018

Differential structural and functional changes in penile and coronary arteries from obese Zucker rats.

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21 August 2018

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21 August 2018

Insulin resistance and impaired functional vasodilation in obese Zucker rats

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21 August 2018

Losartan reduces the increased participation of cyclooxygenase-2-derived products in vascular responses of hypertensive rats.

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Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins

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Vasoactive prostanoids are generated from arachidonic acid by COX-1 and COX-2 in the mouse

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21 August 2018

Hypertension alters role of iNOS, COX-2, and oxidative stress in bradykinin relaxation impairment after LPS in rat cerebral arteries.

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Diabetes impairs endothelium-dependent relaxation of human penile vascular tissues mediated by NO and EDHF.

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Upregulation of prostacyclin synthesis-related gene expression by shear stress in vascular endothelial cells

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12 December 2020

based on heuristic

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Vasoregulatory prostanoid generation proceeds via cyclooxygenase-2 in noninflamed rat lungs

1 reference

https://pubmed.ncbi.nlm.nih.gov/20082610

12 December 2020

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Effects of diabetes and treatment with the antioxidant alpha-lipoic acid on endothelial and neurogenic responses of corpus cavernosum in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/20082610

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2

1 reference

https://pubmed.ncbi.nlm.nih.gov/20082610

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High proportions of erectile dysfunction in men with the metabolic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/20082610

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation of cyclooxygenase 1- and 2-derived prostanoids in mouse kidney and aorta

1 reference

https://pubmed.ncbi.nlm.nih.gov/20082610

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imbalance between endothelium-derived relaxing and contracting factors in mesenteric arteries from aged OLETF rats, a model of Type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20082610

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1476-5381.2009.00553.X

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Europe PubMed Central

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16 January 2020

1 reference

Europe PubMed Central

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16 January 2020

1 reference

Europe PubMed Central

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16 January 2020

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