Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. (Q39273902)

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5 February 2020

title

Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia (English)

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5 February 2020

1

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Olga Roche

8

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5 February 2020

author name string

Roxana I Sufan

2

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5 February 2020

Bing Zhou

3

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Pardeep Heir

4

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Severa Bunda

5

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Stephanie S Sybingco

6

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Samantha N Greer

7

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Samuel A Heathcote

9

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Vinca W K Chow

10

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Lukasz M Boba

11

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Terri D Richmond

12

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Michele M Hickey

13

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Dwayne L Barber

14

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David A Cheresh

15

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M Celeste Simon

16

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5 February 2020

Meredith S Irwin

17

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5 February 2020

William Y Kim

18

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5 February 2020

Michael Ohh

19

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5 February 2020

language of work or name

English

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publication date

19 June 2011

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5 February 2020

volume

17

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5 February 2020

page(s)

845-853

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issue

7

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https://scigraph.springernature.com/pub.10.1038/nm.2370

5 February 2020

exact match

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10 September 2017

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10 September 2017

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10 September 2017

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10 September 2017

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10 September 2017

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The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities

10 September 2017

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The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

10 September 2017

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Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

10 September 2017

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10 September 2017

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Homotypic association between tumour-associated VHL proteins leads to the restoration of HIF pathway

14 September 2017

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14 September 2017

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25 September 2017

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Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia

25 September 2017

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Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice

21 August 2018

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Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene and VHL-haplotype analysis in patients with presumable congenital erythrocytosis.

21 August 2018

1 reference

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Mutations in the VHL gene in sporadic apparently congenital polycythemia

21 August 2018

1 reference

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Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

21 August 2018

1 reference

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Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo-complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase.

21 August 2018

1 reference

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 August 2018

1 reference

In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations

21 January 2018

1 reference

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

21 January 2018

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FAK silencing inhibits leukemogenesis in BCR/ABL-transformed hematopoietic cells

21 January 2018

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Congenital polycythemia with homozygous and heterozygous mutations of von Hippel-Lindau gene: five new Caucasian patients

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21685897

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Different STAT-3 and STAT-5 phosphorylation discriminates among Ph-negative chronic myeloproliferative diseases and is independent of the V617F JAK-2 mutation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21685897

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NM.2370

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21685897%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21685897%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference