Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A. (Q39282348)

10 September 2017

Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A. (English)

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10 September 2017

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Natsuko Yamakawa

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10 September 2017

Umeharu Ohto

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10 September 2017

Sachiko Akashi-Takamura

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Koichiro Takahashi

4

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Shin-Ichiroh Saitoh

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10 September 2017

Natsuko Tanimura

6

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10 September 2017

Takayoshi Suganami

7

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Yoshihiro Ogawa

8

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Takuma Shibata

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Toshiyuki Shimizu

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Kensuke Miyake

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7 September 2012

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10 September 2017

International Immunology

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25

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1

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45-52

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Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large

10 September 2017

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

Toll-like receptor function and signaling

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors

21 January 2018

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Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

Expression of functional D299G.T399I polymorphic variant of TLR4 depends more on coexpression of MD-2 than does wild-type TLR4.

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

TLR4 polymorphisms mediate impaired responses to respiratory syncytial virus and lipopolysaccharide

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling

21 January 2018

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Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers

21 January 2018

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New experimental approaches in retrovirus-mediated expression screening

21 January 2018

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Agonistic antibody to TLR4/MD-2 protects mice from acute lethal hepatitis induced by TNF-alpha

21 January 2018

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The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4.

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

The D299G/T399I Toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

A potent adjuvant monophosphoryl lipid A triggers various immune responses, but not secretion of IL-1beta or activation of caspase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

Toll-like Receptor 4 Polymorphisms and Atherogenesis

21 January 2018

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https://api.crossref.org/works/10.1093%2FINTIMM%2FDXS084

21 January 2018

Identifiers

DOI

10.1093/INTIMM/DXS084

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10 September 2017

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