Synthesis and biological evaluation of 3-aryl-quinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives as hypoxic selective anti-tumor agents. (Q39298066)

PubMed publication ID

22890172

10 September 2017

title

Synthesis and biological evaluation of 3-aryl-quinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives as hypoxic selective anti-tumor agents (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6268107&resulttype=core&format=json

13 May 2020

0 references

Yunzhen Hu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6268107&resulttype=core&format=json

13 May 2020

Qing Xia

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6268107&resulttype=core&format=json

13 May 2020

Shihao Shangguan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6268107&resulttype=core&format=json

13 May 2020

Xiaowen Liu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6268107&resulttype=core&format=json

13 May 2020

Yongzhou Hu

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6268107&resulttype=core&format=json

13 May 2020

Rong Sheng

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6268107&resulttype=core&format=json

13 May 2020

language of work or name

English

0 references

publication date

13 August 2012

1 reference

PubMed publication ID

10 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6268107&resulttype=core&format=json

13 May 2020

volume

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6268107&resulttype=core&format=json

13 May 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6268107&resulttype=core&format=json

13 May 2020

page(s)

9683-9696

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6268107&resulttype=core&format=json

Creative Commons Attribution 4.0 International

13 May 2020

copyright license

start time

13 August 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Exploiting tumour hypoxia in cancer treatment

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES17089683

The importance of radiation chemistry to radiation and free radical biology (The 2008 Silvanus Thompson Memorial Lecture).

21 January 2018

1 reference

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Targeting hypoxia in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES17089683

Tirapazamine, Cisplatin, and Radiation versus Fluorouracil, Cisplatin, and Radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02).

21 January 2018

1 reference

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Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): a phase III trial of the Trans-Tasman Radiation Oncology Group

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES17089683

Hypoxia-selective agents derived from 2-quinoxalinecarbonitrile 1,4-di-N-oxides. 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES17089683

Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES17089683

Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES17089683

New quinoxaline 1, 4-di-N-oxides: anticancer and hypoxia-selective therapeutic agents

21 January 2018

1 reference

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Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors

21 January 2018

1 reference

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Synthesis and hypoxic-cytotoxic activity of some 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES17089683

Synthesis, hypoxia-selective cytotoxicity of new 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES17089683

Synthesis, structure and hypoxic cytotoxicity of 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES17089683

Q39, a novel synthetic Quinoxaline 1,4-Di-N-oxide compound with anti-cancer activity in hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES17089683

Q39, a quinoxaline 1,4-Di-N-oxide derivative, inhibits hypoxia-inducible factor-1α expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES17089683

Anti-T. cruzi activities and QSAR studies of 3-arylquinoxaline-2-carbonitrile di-N-oxides

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES17089683

Synthesis and structure-activity relationship of 3-phenylquinoxaline 1,4-di-N-oxide derivatives as antimalarial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES17089683

De novo parallel design, synthesis and evaluation of inhibitors against the reverse transcriptase of human immunodeficiency virus type-1 and drug-resistant variants

21 January 2018

1 reference

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Potential antiarthritic agents. 2. Benzoylacetonitriles and .beta.-aminocinnamonitriles

21 January 2018

1 reference

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Tirapazamine cytotoxicity for neuroblastoma is p53 dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES17089683

Synthesis and antimalarial activity of new 3-arylquinoxaline-2-carbonitrile derivatives

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22890172

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Synthesis and cytotoxic activity of 3-phenyl-2-thio-quinoxaline 1,4-dioxide derivatives in hypoxia and in normoxia.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22890172

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3390/MOLECULES17089683

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6268107&resulttype=core&format=json

release_5i7yvnndajcz5jnrlaegxwepwi

13 May 2020

Fatcat ID

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6268107&resulttype=core&format=json

13 May 2020

PubMed publication ID

22890172

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6268107&resulttype=core&format=json