IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. (Q39299575)

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English	IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.	scientific article

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10 February 2020

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress (English)

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inflammasome complex

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Nathaniel Heintz

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Nathaniel Heintz

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Qizhi Tang

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Myriam Heiman

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Alana G Lerner

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John-Paul Upton

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P V K Praveen

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Rajarshi Ghosh

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Yoshimi Nakagawa

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Sarah Shen

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Vinh Nguyen

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Bradley J Backes

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Simon Hui

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Scott A Oakes

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Feroz R Papa

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publication date

1 August 2012

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10 February 2020

Cell Metabolism

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10 February 2020

16

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250-264

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2

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10 February 2020

Inflammasomes in health and disease

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10 September 2017

Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response

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Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease

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Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation

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Signaling cell death from the endoplasmic reticulum stress response

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Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

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Regulation of mRNA translation and stability by microRNAs

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The UPR and cell fate at a glance

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Tandem ChoRE and CCAAT motifs and associated factors regulate Txnip expression in response to glucose or adenosine-containing molecules

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10 September 2017

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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Messenger RNA targeting to endoplasmic reticulum stress signalling sites.

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10 September 2017

Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions

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A translational profiling approach for the molecular characterization of CNS cell types

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One step at a time: endoplasmic reticulum-associated degradation

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Regulation of hepatic lipogenesis by the transcription factor XBP1

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The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes

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Txnip balances metabolic and growth signaling via PTEN disulfide reduction

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10 September 2017

Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis

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Insulin gene mutations as a cause of permanent neonatal diabetes

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TXNIP regulates peripheral glucose metabolism in humans

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Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins

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The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response

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10 September 2017

The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange

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10 September 2017

Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis

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Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line

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10 September 2017

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

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Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum.

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Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

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10 September 2017

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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10 September 2017

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

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A possible interaction of thioredoxin with VDUP1 in HeLa cells detected in a yeast two-hybrid system

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10 September 2017

Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression

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Transport and assembly processes in the endoplasmic reticulum

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IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

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Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.

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A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress

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21 August 2018

Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals

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21 August 2018

Oligonucleotide microarray analysis of intact human pancreatic islets: identification of glucose-responsive genes and a highly regulated TGFbeta signaling pathway

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21 August 2018

Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome

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12 October 2022

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