Thr435 phosphorylation regulates RelA (p65) NF-kappaB subunit transactivation (Q39301372)

10 September 2017

Thr435 phosphorylation regulates RelA (p65) NF-kappaB subunit transactivation (English)

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10 September 2017

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1 reference

John M O'Shea

1

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PMCID

2829238

10 September 2017

Neil D Perkins

series ordinal

2

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PMCID

2829238

10 September 2017

language of work or name

English

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publication date

24 February 2010

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10 September 2017

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10 September 2017

426

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10 September 2017

3

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10 September 2017

345-354

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Creative Commons Attribution-NonCommercial 2.5 Generic

10 September 2017

start time

25 July 2019

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

The peptidyl-prolyl isomerase, Pin1, facilitates NF-kappaB binding in hepatocytes and protects against hepatic ischemia/reperfusion injury

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GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA

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Two modes of transcriptional activation at native promoters by NF-kappaB p65

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Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination

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SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

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Regulation of the RelA (p65) transactivation domain

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Repression of gene expression by unphosphorylated NF-kappaB p65 through epigenetic mechanisms.

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RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexes

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Shared principles in NF-kappaB signaling

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Introduction to NF-kappaB: players, pathways, perspectives

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NF-kappaB RelA phosphorylation regulates RelA acetylation

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Sp1-associated activation of macrophage inflammatory protein-2 promoter by CpG-oligodeoxynucleotide and lipopolysaccharide

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cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B.

10 September 2017

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Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding [...]

10 September 2017

1 reference

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Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity

10 September 2017

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Nuclear factor-kappaB: its role in health and disease

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Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation

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The large subunit of replication factor C interacts with the histone deacetylase, HDAC1

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The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1

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1 reference

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The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression

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1 reference

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Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II

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The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).

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An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

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NF-kappa B subunit-specific regulation of the interleukin-8 promoter

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1 reference

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Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B

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1 reference

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1 reference

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1 reference

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IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation

14 September 2017

1 reference

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IKKbeta phosphorylates p65 at S468 in transactivaton domain 2.

14 September 2017

1 reference

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1 reference

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Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.

14 September 2017

1 reference

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14 September 2017

1 reference

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IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829238

A novel form of the RelA nuclear factor kappaB subunit is induced by and forms a complex with the proto-oncogene c-Myc.

14 September 2017

1 reference

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Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines.

25 September 2017

1 reference

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Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829238

Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829238

Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829238

Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829238

Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829238

The NF-kappa B activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829238

p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor

21 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1042%2FBJ20091630

21 January 2018

Identifiers

DOI

10.1042/BJ20091630

1 reference

10 September 2017

1 reference

10 September 2017

1 reference

PMCID

2829238