Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways (Q39302766)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22862290%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways (English)

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9 February 2020

1 reference

5

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C. Oliver Kappe

8

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9 February 2020

Christoph Romanin

9

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9 February 2020

Klaus Groschner

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author name string

H Schleifer

1

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9 February 2020

B Doleschal

2

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M Lichtenegger

3

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R Oppenrieder

4

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I Frischauf

6

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T N Glasnov

7

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language of work or name

English

0 references

publication date

1 December 2012

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British Journal of Pharmacology

9 February 2020

published in

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volume

167

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issue

8

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page(s)

1712-1722

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describes a project that uses

9 February 2020

ImageJ

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11 June 2022

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10 September 2017

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Increased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutant

10 September 2017

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10 September 2017

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Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

10 September 2017

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Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions.

10 September 2017

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10 September 2017

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Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry

10 September 2017

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Canonical transient receptor potential 5 channel in conjunction with Orai1 and STIM1 allows Sr2+ entry, optimal influx of Ca2+, and degranulation in a rat mast cell line

10 September 2017

1 reference

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Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate

10 September 2017

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10 September 2017

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10 September 2017

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10 September 2017

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10 September 2017

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10 September 2017

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10 September 2017

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TH1 and TH2 cytokine inhibition by 3,5-bis(trifluoromethyl)pyrazoles, a novel class of immunomodulators

10 September 2017

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Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds

10 September 2017

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The versatility and universality of calcium signalling

10 September 2017

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10 September 2017

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Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

10 September 2017

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Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2.

10 September 2017

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Sustained activation of the tyrosine kinase Syk by antigen in mast cells requires local Ca2+ influx through Ca2+ release-activated Ca2+ channels

10 September 2017

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Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.

14 September 2017

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The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.

14 September 2017

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A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2.

14 September 2017

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14 September 2017

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Comparison of human TRPC3 channels in receptor-activated and store-operated modes. Differential sensitivity to channel blockers suggests fundamental differences in channel composition

14 September 2017

1 reference

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Expression of Trp3 determines sensitivity of capacitative Ca2+ entry to nitric oxide and mitochondrial Ca2+ handling: evidence for a role of Trp3 as a subunit of capacitative Ca2+ entry channels.

25 September 2017

1 reference

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Depletion of intracellular calcium stores activates a calcium current in mast cells

25 September 2017

1 reference

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Transient receptor potential canonical 3 (TRPC3) mediates thrombin-induced astrocyte activation and upregulates its own expression in cortical astrocytes.

15 June 2018

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Discrimination between receptor- and store-operated Ca(2+) influx in human neutrophils

21 August 2018

1 reference

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High-speed microwave-assisted synthesis of the trifluoromethylpyrazol-derived canonical transient receptor potential (TRPC) channel inhibitor Pyr3.

21 August 2018

1 reference

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Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: synthesis and CRAC channel inhibitory activity of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides

21 August 2018

1 reference

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Orai1 mediates the interaction between STIM1 and hTRPC1 and regulates the mode of activation of hTRPC1-forming Ca2+ channels

21 August 2018

1 reference

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Preliminary in vivo pharmacokinetic and pharmacodynamic evaluation of a novel calcineurin-independent inhibitor of NFAT.

21 August 2018

1 reference

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Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2.

21 August 2018

1 reference

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A Pyrazole Derivative, YM-58483, Potently Inhibits Store-Operated Sustained Ca2+ Influx and IL-2 Production in T Lymphocytes

21 August 2018

1 reference

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Microwave-assisted and continuous flow multistep synthesis of 4-(pyrazol-1-yl)carboxanilides

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22862290

12 December 2020

inferred from PubMed ID database lookup

Calcium release-activated calcium current in rat mast cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22862290

12 December 2020

inferred from PubMed ID database lookup

3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22862290

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1111/J.1476-5381.2012.02126.X

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22862290%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22862290%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

22862290

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22862290%20AND%20SRC:MED&resulttype=core&format=json