Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells (Q39312837)

10 September 2017

Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells (English)

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10 September 2017

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Cheng-Fu Zhou

1

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10 September 2017

Xue-Bing Li

2

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10 September 2017

Heng Sun

3

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10 September 2017

Bo Zhang

4

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10 September 2017

Yu-Song Han

5

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10 September 2017

Yi Jiang

6

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10 September 2017

Qiu-Lin Zhuang

7

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10 September 2017

Jing Fang

8

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10 September 2017

Guo-Hao Wu

9

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10 September 2017

18 July 2012

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10 September 2017

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10 September 2017

64

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10 September 2017

9

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10 September 2017

775-782

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Glucose avidity of carcinomas.

10 September 2017

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Human pyruvate kinase M2: a multifunctional protein

21 January 2018

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Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis?

21 January 2018

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RETRACTED: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

21 January 2018

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Cancer: Sacrifice for survival.

21 January 2018

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On the Origin of Cancer Cells

21 January 2018

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Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes

21 January 2018

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

21 January 2018

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

21 January 2018

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The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate

21 January 2018

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Pyruvate kinase type M2 and its role in tumor growth and spreading

21 January 2018

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

21 January 2018

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Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

21 January 2018

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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein

21 January 2018

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Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7.

21 January 2018

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MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells

21 January 2018

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Metabolic state of glioma stem cells and nontumorigenic cells

21 January 2018

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Glycolytic phenotype in breast cancer: activation of Akt, up-regulation of GLUT1, TKTL1 and down-regulation of M2PK.

21 January 2018

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21 January 2018

Cancer statistics, 2010

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Present status and perspectives of colorectal cancer in Asia: Colorectal Cancer Working Group report in 30th Asia-Pacific Cancer Conference

21 January 2018

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Toward optimized front-line therapeutic strategies in patients with metastatic colorectal cancer--an expert review from the International Congress on Anti-Cancer Treatment (ICACT) 2009.

21 January 2018

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Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity

21 January 2018

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Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase

21 January 2018

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Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation

21 January 2018

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The metabolic marker tumour pyruvate kinase type M2 (tumour M2-PK) shows increased expression along the metaplasia-dysplasia-adenocarcinoma sequence in Barrett's oesophagus

21 January 2018

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No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

21 January 2018

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Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply

21 January 2018

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Metabolic mapping with bioluminescence: basic and clinical relevance

21 January 2018

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Breast cancer stromal myxoid changes are associated with tumor invasion and metastasis: a central role for hyaluronan

21 January 2018

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Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion

21 January 2018

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Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

21 January 2018

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Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

21 January 2018

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Cancer's craving for sugar: an opportunity for clinical exploitation

21 January 2018

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Causes and consequences of increased glucose metabolism of cancers

21 January 2018

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Why do cancers have high aerobic glycolysis?

21 January 2018

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Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2.

21 January 2018

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Lactate stimulates endothelial cell migration.

21 January 2018

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Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis

21 January 2018

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Regulation of tumor pH and the role of carbonic anhydrase 9.

21 January 2018

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Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IUB.1066

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10 September 2017

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