Activity of the selective IκB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia: involvement of FOXO3a (Q39328413)

11 September 2017

Activity of the selective IκB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia: involvement of FOXO3a (English)

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T-cell acute lymphoblastic leukemia

11 September 2017

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lymphoblastic leukemia

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based on heuristic

inferred from title

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Francesca Chiarini

2

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Francesca Buontempo

Francesca Buontempo

1

0 references

Luca Maria Neri

Luca M Neri

8

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Andrea Pession

Andrea Pession

6

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James A. McCubrey

James A McCubrey

9

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Milena Fini

Milena Fini

7

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author name string

Daniela Bressanin

3

1 reference

11 September 2017

Giovanna Tabellini

4

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11 September 2017

Fraia Melchionda

5

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11 September 2017

Alberto M Martelli

10

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11 September 2017

language of work or name

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1 July 2012

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11 September 2017

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11 September 2017

11

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11 September 2017

13

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11 September 2017

2467-2475

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Acute lymphoblastic leukaemia

11 September 2017

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Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia

21 January 2018

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The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL-BFM 2000 protocol can be separated from FBXW7 loss of function

21 January 2018

1 reference

Ligand-driven activation of the notch pathway in T-ALL and solid tumors: why Not(ch)?

21 January 2018

1 reference

Notch in T-ALL: new players in a complex disease.

21 January 2018

1 reference

Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think.

21 January 2018

1 reference

Fine-tuning of the intracellular canonical Notch signaling pathway.

21 January 2018

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

1 reference

Notch, a unifying target in T-cell acute lymphoblastic leukemia?

21 January 2018

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Notch1 augments NF-kappaB activity by facilitating its nuclear retention

21 January 2018

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Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

21 January 2018

1 reference

Nuclear factor-kappaB in cancer development and progression

21 January 2018

1 reference

A critical role for the NFkB pathway in multiple myeloma

21 January 2018

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The NFκB pathway: a therapeutic target in glioblastoma

21 January 2018

1 reference

Regulation and function of NF-kappaB transcription factors in the immune system

21 January 2018

1 reference

Molecular pathogenesis of T-cell leukaemia and lymphoma

21 January 2018

1 reference

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

21 January 2018

1 reference

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

1 reference

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

21 January 2018

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Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

21 January 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

21 January 2018

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IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

21 January 2018

1 reference

A new fork for clinical application: targeting forkhead transcription factors in cancer

21 January 2018

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Highly phosphorylated FOXO3A is an adverse prognostic factor in acute myeloid leukemia

21 January 2018

1 reference

IκB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia

21 January 2018

1 reference

Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs

21 January 2018

1 reference

BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice

21 January 2018

1 reference

IKK mediates ischemia-induced neuronal death

21 January 2018

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BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways

21 January 2018

1 reference

Targeting NF-kappaB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells.

21 January 2018

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ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

21 January 2018

1 reference

Akt inhibitors in clinical development for the treatment of cancer

21 January 2018

1 reference

Apoptotic role of IKK in T-ALL therapeutic response.

21 January 2018

1 reference

The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.

21 January 2018

1 reference

Gene-based outcome prediction in multiple cohorts of pediatric T-cell acute lymphoblastic leukemia: a Children's Oncology Group study

21 January 2018

1 reference

The emerging roles of forkhead box (Fox) proteins in cancer

21 January 2018

1 reference

Exploiting p53 status to enhance effectiveness of chemotherapy by lowering associated toxicity

21 January 2018

1 reference

Sensitivity of acute myeloid leukemia Kasumi-1 cells to binase toxic action depends on the expression of KIT and АML1-ETO oncogenes

21 January 2018

1 reference

Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling

21 January 2018

1 reference

Mechanism of action of the multikinase inhibitor Foretinib.

21 January 2018

1 reference

Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop.

21 January 2018

1 reference

MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4161/CC.20859

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11 September 2017

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