Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. (Q39328422)

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English	Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma.	scientific article

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24 March 2020

Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma (English)

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Diana I Sánchez

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Bárbara González-Fernández

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Javier González-Gallego

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María J. Tuñón

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Beatriz San-Miguel

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Juan Ortiz de Urbina

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9 November 2016

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Journal of Pineal Research

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62

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1

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24 March 2020

Cancer statistics, 2015

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12369

21 January 2018

New advances in hepatocellular carcinoma

1 reference

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21 January 2018

Sphingosine-1-phosphate signaling and its role in disease

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21 January 2018

Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation

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21 January 2018

The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined

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Sphingosine kinase 1 as an anticancer therapeutic target

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A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy

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21 January 2018

Sphingosine 1-phosphate and cancer

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21 January 2018

Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation

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First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.

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21 January 2018

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

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21 January 2018

Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway

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21 January 2018

Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo

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Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.

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21 January 2018

The blockage of Ras/ERK pathway augments the sensitivity of SphK1 inhibitor SKI II in human hepatoma HepG2 cells

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21 January 2018

Melatonin: an ancient molecule that makes oxygen metabolically tolerable.

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21 January 2018

Melatonin as a treatment for gastrointestinal cancer: a review.

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21 January 2018

Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus

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21 January 2018

Melatonin limits the expression of profibrogenic genes and ameliorates the progression of hepatic fibrosis in mice.

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21 January 2018

Melatonin's role in preventing toxin-related and sepsis-mediated hepatic damage: A review.

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Melatonin: a potential intervention for hepatic steatosis

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Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line

1 reference

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21 January 2018

Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.

1 reference

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21 January 2018

Inhibition of matrix metalloproteinase-9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in HepG2 liver cancer cells.

1 reference

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21 January 2018

Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis

1 reference

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21 January 2018

Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin.

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12369

21 January 2018

Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1α inactivation in hypoxic PC-3 prostate cancer cells

1 reference

https://api.crossref.org/works/10.1111%2FJPI.12369

21 January 2018

Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis

1 reference

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21 January 2018

Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma.

1 reference

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21 January 2018

Role for sphingosine kinase 1 in colon carcinogenesis.

1 reference

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21 January 2018

Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation

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21 January 2018

Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation

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21 January 2018

Sphingosine 1-phosphate induces vascular endothelial growth factor expression in endothelial cells

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21 January 2018

A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC).

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21 January 2018

FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation

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21 January 2018

FTY720 (Fingolimod) sensitizes hepatocellular carcinoma cells to sorafenib-mediated cytotoxicity

1 reference

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21 January 2018

Tumor necrosis factor-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression

1 reference

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21 January 2018

Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence.

1 reference

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21 January 2018

Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs

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Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.

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High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients

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Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity

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PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells.

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Melatonin reverses tunicamycin-induced endoplasmic reticulum stress in human hepatocellular carcinoma cells and improves cytotoxic response to doxorubicin by increasing CHOP and decreasing survivin

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Raf kinase inhibitor protein mediated signaling inhibits invasion and metastasis of hepatocellular carcinoma.

1 reference

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Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma.

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Silencing STAT3 may inhibit cell growth through regulating signaling pathway, telomerase, cell cycle, apoptosis and angiogenesis in hepatocellular carcinoma: potential uses for gene therapy

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Activated Rac1 regulates the degradation of IκBα and the nuclear translocation of STAT3-NFκB complexes in starved cancer cells

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STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.

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The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications

1 reference

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Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways

1 reference

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21 January 2018

SPHK1 regulates proliferation and survival responses in triple-negative breast cancer

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A natural piper-amide-like compound NED-135 exhibits a potent inhibitory effect on the invasive breast cancer cells

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Quercetin Administration Ameliorates Pulmonary Complications of Cirrhosis in Rats

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N-acetyl-cysteine protects liver from apoptotic death in an animal model of fulminant hepatic failure

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10.1111/JPI.12369

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24 March 2020

1 reference

Europe PubMed Central

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24 March 2020

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