A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells (Q39363398)

11 September 2017

title

A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells (English)

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11 September 2017

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7

Joachim Grötzinger

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Kosuke Yamamoto

object named as

Kosuke Yamamoto

1

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Stefan Rose-John

object named as

Stefan Rose-John

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author name string

Ahmad Trad

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11 September 2017

Anja Baumgart

3

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11 September 2017

Linda Hüske

4

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11 September 2017

Inken Lorenzen

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11 September 2017

Athena Chalaris

6

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11 September 2017

Joachim Grötzinger

7

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11 September 2017

Tobias Dechow

8

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11 September 2017

Jürgen Scheller

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11 September 2017

language of work or name

English

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publication date

1 July 2012

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11 September 2017

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11 September 2017

volume

445

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11 September 2017

issue

1

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11 September 2017

page(s)

135-144

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A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

11 September 2017

cites work

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Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

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Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)

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ADAM17: a molecular switch to control inflammation and tissue regeneration

21 January 2018

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In vivo role of leukocyte ADAM17 in the inflammatory and host responses during E. coli-mediated peritonitis

21 January 2018

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ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase

21 January 2018

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MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands

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ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking

21 January 2018

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Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

21 January 2018

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iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS

21 January 2018

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TACE: a new target in epidermal growth factor receptor dependent tumors

21 January 2018

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ADAM17 as a therapeutic target in multiple diseases.

21 January 2018

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Multiple mechanisms are responsible for transactivation of the epidermal growth factor receptor in mammary epithelial cells.

21 January 2018

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ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer

21 January 2018

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Up-regulated expression of ADAM17 in human colon carcinoma: co-expression with EGFR in neoplastic and endothelial cells

21 January 2018

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Aberrant expression of a disintegrin and metalloproteinase 17/tumor necrosis factor-alpha converting enzyme increases the malignant potential in human pancreatic ductal adenocarcinoma

21 January 2018

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ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers

21 January 2018

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ADAM17 promotes glioma cell malignant phenotype

21 January 2018

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ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation

21 January 2018

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Tumor regression in cancer patients by very low doses of a T cell-engaging antibody

21 January 2018

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T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells

21 January 2018

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Development of sandwich ELISA for detection and quantification of human and murine a disintegrin and metalloproteinase17.

21 January 2018

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A rapid and scalable method for selecting recombinant mouse monoclonal antibodies

21 January 2018

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RT-PCR cloning and characterization of mouse immunoglobulin variable domains with high affinity for HLA-DR antigens

21 January 2018

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Specific killing of lymphoma cells by cytotoxic T-cells mediated by a bispecific diabody

21 January 2018

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Specific targeting of cytokine-secreting cells: a bispecific diabody recognizing human interleukin-6 and CD3 induces T cell-mediated killing

21 January 2018

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Bispecific T-cell engaging antibodies for cancer therapy

21 January 2018

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Potent control of tumor growth by CEA/CD3-bispecific single-chain antibody constructs that are not competitively inhibited by soluble CEA.

21 January 2018

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Antitumor activity of an EpCAM/CD3-bispecific BiTE antibody during long-term treatment of mice in the absence of T-cell anergy and sustained cytokine release

21 January 2018

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The soluble Interleukin 6 receptor: generation and role in inflammation and cancer

21 January 2018

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Therapeutic benefits from targeting of ADAM family members

21 January 2018

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Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

21 January 2018

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Targeting TACE-dependent EGFR ligand shedding in breast cancer

21 January 2018

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The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

21 January 2018

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The RAF inhibitor paradox revisited

21 January 2018

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Two-Point Calibration of Circular Dichrometer with d-10-Camphorsulfonic Acid

21 January 2018

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21 January 2018

Identifiers

DOI

10.1042/BJ20120433

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11 September 2017

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