A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells (Q39366387)

11 September 2017

A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells (English)

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11 September 2017

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7

Gregory J Gores

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11 September 2017

Rory L Smoot

1

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11 September 2017

Boris R A Blechacz

2

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11 September 2017

Nathan W Werneburg

3

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11 September 2017

Steve F Bronk

4

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11 September 2017

Frank A Sinicrope

5

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11 September 2017

Alphonse E Sirica

6

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11 September 2017

language of work or name

English

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publication date

16 February 2010

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70

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5

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1960-1969

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describes a project that uses

11 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2831099/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

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Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2.

11 September 2017

1 reference

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Principles of cancer therapy: oncogene and non-oncogene addiction

11 September 2017

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Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy

11 September 2017

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BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells

11 September 2017

1 reference

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Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins

11 September 2017

1 reference

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Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

11 September 2017

1 reference

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BAX activation is initiated at a novel interaction site

11 September 2017

1 reference

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Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia

11 September 2017

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Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?

11 September 2017

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Diagnosing and exploiting cancer's addiction to blocks in apoptosis

11 September 2017

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The BCL-2 protein family: opposing activities that mediate cell death

11 September 2017

1 reference

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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

11 September 2017

1 reference

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BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

11 September 2017

1 reference

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

11 September 2017

1 reference

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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

11 September 2017

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

11 September 2017

1 reference

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Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States

11 September 2017

1 reference

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

11 September 2017

1 reference

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Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis

11 September 2017

1 reference

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

11 September 2017

1 reference

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Structure of Bax: coregulation of dimer formation and intracellular localization

11 September 2017

1 reference

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11 September 2017

The Hallmarks of Cancer

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Regulated targeting of BAX to mitochondria.

11 September 2017

1 reference

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Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831099

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831099

BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831099

A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831099

Tumor necrosis factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins

14 September 2017

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erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer

14 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831099

Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831099

A role for mitochondrial Bak in apoptotic response to anticancer drugs

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831099

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831099

Biliary adenocarcinoma. Characterisation of three new human tumor cell lines.

15 June 2018

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Establishment and characterization of a human combined hepatocholangiocarcinoma cell line and its heterologous transplantation in nude mice

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831099

A new human cholangiocellular carcinoma cell line (HuCC-T1) producing carbohydrate antigen 19/9 in serum-free medium

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831099

Different forms of cell death induced by putative BCL2 inhibitors.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831099

A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831099

Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831099

Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20160031

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20160031

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-09-3535

1 reference

11 September 2017

1 reference

11 September 2017

PubMed publication ID

20160031

1 reference