Curcumin abrogates bile-induced NF-κB activity and DNA damage in vitro and suppresses NF-κB activity whilst promoting apoptosis in vivo, suggesting chemopreventative potential in Barrett's oesophagus. (Q39367849)

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English	Curcumin abrogates bile-induced NF-κB activity and DNA damage in vitro and suppresses NF-κB activity whilst promoting apoptosis in vivo, suggesting chemopreventative potential in Barrett's oesophagus.	scientific article

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28 January 2020

Curcumin abrogates bile-induced NF-κB activity and DNA damage in vitro and suppresses NF-κB activity whilst promoting apoptosis in vivo, suggesting chemopreventative potential in Barrett's oesophagus (English)

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28 January 2020

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apoptotic process

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28 January 2020

Zakaria Eltahir

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28 January 2020

Gareth J Jenkins

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28 January 2020

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N Rawat

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28 January 2020

A Alhamdani

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28 January 2020

E McAdam

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28 January 2020

P Lewis

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28 January 2020

P Griffiths

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28 January 2020

J N Baxter

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28 January 2020

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1 April 2012

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28 January 2020

Clinical and Translational Oncology

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28 January 2020

14

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28 January 2020

4

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28 January 2020

302-311

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28 January 2020

Prevalence of metaplasia at the gastro-oesophageal junction

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21 January 2018

Prevalence of Barrett's esophagus in the general population: an endoscopic study

1 reference

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21 January 2018

Reflux, Barrett's oesophagus and adenocarcinoma: burning questions

1 reference

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21 January 2018

NF-kappaB activation in esophageal adenocarcinoma: relationship to Barrett's metaplasia, survival, and response to neoadjuvant chemoradiotherapy

1 reference

https://api.crossref.org/works/10.1007%2FS12094-012-0799-X

21 January 2018

The bile acid deoxycholic acid (DCA) at neutral pH activates NF-kappaB and induces IL-8 expression in oesophageal cells in vitro

1 reference

https://api.crossref.org/works/10.1007%2FS12094-012-0799-X

21 January 2018

Aberrant rel/nfkb genes and activity in human cancer

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21 January 2018

Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death

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21 January 2018

Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.

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21 January 2018

Implication of duodenogastric reflux in the pathogenesis of Barrett's oesophagus

1 reference

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21 January 2018

Upregulation of the oncogene c-myc in Barrett's adenocarcinoma: induction of c-myc by acidified bile acid in vitro

1 reference

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21 January 2018

The bile acid deoxycholic acid has a non-linear dose response for DNA damage and possibly NF-kappaB activation in oesophageal cells, with a mechanism of action involving ROS.

1 reference

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21 January 2018

In vitro and in vivo anti-tumoral effect of curcumin against melanoma cells

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Phase II trial of curcumin in patients with advanced pancreatic cancer

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Immunomodulatory activity of curcumin: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro

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Biological properties of curcumin-cellular and molecular mechanisms of action

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Ferula asa-foetida and Curcuma longa in traditional medical treatment and diet in Nepal

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Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products

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21 January 2018

The in vitro micronucleus technique

1 reference

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21 January 2018

Toxic bile acids in gastro-oesophageal reflux disease: influence of gastric acidity

1 reference

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21 January 2018

Immunohistochemical study of nuclear factor-kappaB activity and interleukin-8 abundance in oesophageal adenocarcinoma; a useful strategy for monitoring these biomarkers.

1 reference

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21 January 2018

Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance

1 reference

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21 January 2018

Dose escalation of a curcuminoid formulation

1 reference

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21 January 2018

Detection of oxidative DNA damage in oesophageal biopsies of patients with reflux symptoms and normal pH monitoring

1 reference

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21 January 2018

NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway

1 reference

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21 January 2018

Autocrine and paracrine regulation by cytokines and growth factors in melanoma

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21 January 2018

Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation

1 reference

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21 January 2018

Proinflammatory cytokine and nuclear factor kappa-B expression along the inflammation-metaplasia-dysplasia-adenocarcinoma sequence in the esophagus

1 reference

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21 January 2018

Activation of NFkappaB represents the central event in the neoplastic progression associated with Barrett's esophagus: a possible link to the inflammation and overexpression of COX-2, PPARgamma and growth factors

1 reference

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21 January 2018

Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB.

1 reference

https://api.crossref.org/works/10.1007%2FS12094-012-0799-X

21 January 2018

Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells

1 reference

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21 January 2018

Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS12094-012-0799-X

21 January 2018

Expression of apoptosis-related proteins in Barrett's metaplasia-dysplasia-carcinoma sequence: a switch to a more resistant phenotype.

1 reference

https://api.crossref.org/works/10.1007%2FS12094-012-0799-X

21 January 2018

Modification of insulin-like growth factor 1 receptor, c-Src, and Bcl-XL protein expression during the progression of Barrett's neoplasia

1 reference

https://api.crossref.org/works/10.1007%2FS12094-012-0799-X

21 January 2018

Unlike esophageal squamous cells, Barrett's epithelial cells resist apoptosis by activating the nuclear factor-kappaB pathway

1 reference

https://api.crossref.org/works/10.1007%2FS12094-012-0799-X

21 January 2018

Apoptotic and proliferative activity in the neoplastic progression of Barrett's oesophagus: a comparative study

1 reference

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21 January 2018

Curcumin induces apoptosis-independent death in oesophageal cancer cells.

1 reference

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21 January 2018

Curcumin promotes apoptosis, increases chemosensitivity, and inhibits nuclear factor kappaB in esophageal adenocarcinoma

1 reference

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21 January 2018

Ethnicity, gender, and socioeconomic status as risk factors for esophagitis and Barrett's esophagus

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Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy

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21 January 2018

Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells

1 reference

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21 January 2018

Barrett's metaplasia

1 reference

https://api.crossref.org/works/10.1007%2FS12094-012-0799-X

21 January 2018

Diet and risk of esophageal cancer by histologic type in a low-risk population

1 reference

https://pubmed.ncbi.nlm.nih.gov/22484638

12 December 2020

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Effect of curcuma on radiation-induced apoptosis in human cancer cells

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12 December 2020

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Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis

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Antioxidants and cancers of the esophagus and gastric cardia

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Deoxycholic acid at neutral and acid pH, is genotoxic to oesophageal cells through the induction of ROS: The potential role of anti-oxidants in Barrett's oesophagus

1 reference

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Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions

1 reference

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Barrett's esophagus: age, prevalence, and extent of columnar epithelium

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Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers

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Duodenoesophageal reflux and the development of esophageal adenocarcinoma in rats

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Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8.

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Diminution of singlet oxygen-induced DNA damage by curcumin and related antioxidants

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1 reference

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