Hsp90 inhibitor NVP-AUY922 enhances radiation sensitivity of tumor cell lines under hypoxia. (Q39404697)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

Hsp90 inhibitor NVP-AUY922 enhances radiation sensitivity of tumor cell lines under hypoxia (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

0 references

1 reference

ChEBI release 2020-05-28

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Vladimir L. Sukhorukov

9

object named as

Vladimir L Sukhorukov

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1

Cholpon S Djuzenova

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

10

Michael Flentje

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

author name string

Christina Blassl

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Konstanze Roloff

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Sebastian Kuger

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Astrid Katzer

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Natalia Niewidok

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Nadine Günther

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

publication date

1 April 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

Cancer Biology and Therapy

21 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

page(s)

425-434

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22286776%20AND%20SRC:MED&resulttype=core&format=json

Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability.

21 January 2020

cites work

1 reference

Hypoxic tumors and their effect on immune cells and cancer therapy

21 January 2018

1 reference

Hypoxia--a key regulatory factor in tumour growth

21 January 2018

1 reference

The potential role of intrinsic hypoxia markers as prognostic variables in cancer

21 January 2018

1 reference

Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis

21 January 2018

1 reference

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

21 January 2018

1 reference

Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways

21 January 2018

1 reference

Heat shock protein 90: the cancer chaperone

21 January 2018

1 reference

Targeting HSP90 for cancer therapy

21 January 2018

1 reference

Altered states: selectively drugging the Hsp90 cancer chaperone

21 January 2018

1 reference

21 January 2018

The Hallmarks of Cancer

1 reference

Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor

21 January 2018

1 reference

Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin

21 January 2018

1 reference

Heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor

21 January 2018

1 reference

Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin

21 January 2018

1 reference

Radiosensitization of human vascular endothelial cells through Hsp90 inhibition with 17-N-allilamino-17-demethoxygeldanamycin

21 January 2018

1 reference

Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation

21 January 2018

1 reference

Inhibition of hsp90 compromises the DNA damage response to radiation

21 January 2018

1 reference

Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction

21 January 2018

1 reference

Antitumor activity of NVP-AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteins

21 January 2018

1 reference

Combined effects of novel heat shock protein 90 inhibitor NVP-AUY922 and nilotinib in a random mutagenesis screen

21 January 2018

1 reference

ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation

21 January 2018

1 reference

Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance.

21 January 2018

1 reference

Evidence supporting a signal transduction pathway leading to the radiation-resistant phenotype in human tumor cells

21 January 2018

1 reference

Detecting changes in tumor hypoxia with carbonic anhydrase IX and pimonidazole

21 January 2018

1 reference

HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair

21 January 2018

1 reference

Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis

21 January 2018

1 reference

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

1 reference

Hypoxia links ATR and p53 through replication arrest

21 January 2018

1 reference

Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800.

21 January 2018

1 reference

NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models

21 January 2018

1 reference

Cisplatin abrogates the geldanamycin-induced heat shock response

21 January 2018

1 reference

Recent advances in Hsp90 inhibitors as antitumor agents

21 January 2018

1 reference

New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential.

21 January 2018

1 reference

Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone

21 January 2018

1 reference

NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis

21 January 2018

1 reference

Phosphorylation of histone H2AX as a measure of radiosensitivity

21 January 2018

1 reference

ATM activation and signaling under hypoxic conditions.

21 January 2018

1 reference

Differential response of human glioblastoma cell lines to combined camptothecin and ionizing radiation treatment

21 January 2018

1 reference

Characterization of carbonic anhydrase IX (CA IX) as an endogenous marker of chronic hypoxia in live human tumor cells.

21 January 2018

1 reference

An optimized method for measurement of gamma-H2AX in blood mononuclear and cultured cells

21 January 2018

1 reference