UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression. (Q39404751)

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21 January 2020

title

UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression (English)

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21 January 2020

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1

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21 January 2020

Vincenzo Carafa

4

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21 January 2020

Angela Nebbioso

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21 January 2020

Carmelo Laudanna

9

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21 January 2020

Michele Ceccarelli

10

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21 January 2020

Lucia Altucci

11

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21 January 2020

author name string

A Fucci

2

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21 January 2020

M Pancione

3

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21 January 2020

C Pistore

6

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21 January 2020

F Babbio

7

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21 January 2020

C Votino

8

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21 January 2020

I M Bonapace

12

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21 January 2020

V Colantuoni

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language of work or name

English

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publication date

30 January 2012

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21 January 2020

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21 January 2020

volume

31

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21 January 2020

issue

49

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21 January 2020

page(s)

5061-5072

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UHRF1 plays a role in maintaining DNA methylation in mammalian cells

21 January 2020

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Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells

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DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer

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Colorectal cancer expression of peroxisome proliferator-activated receptor gamma (PPARG, PPARgamma) is associated with good prognosis

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Retracted: Epigenetic Silencing of Peroxisome Proliferator-Activated Receptor γ Is a Biomarker for Colorectal Cancer Progression and Adverse Patients' Outcome

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Np95 is implicated in pericentromeric heterochromatin replication and in major satellite silencing

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A novel peroxisome proliferator-activated receptor gamma isoform with dominant negative activity generated by alternative splicing

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The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

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UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis

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ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain

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Identifiers

DOI

10.1038/ONC.2012.3

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21 January 2020

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