Affinity purification using recombinant PXR as a tool to characterize environmental ligands. (Q39416595)

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19 January 2020

title

Affinity purification using recombinant PXR as a tool to characterize environmental ligands (English)

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5

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Vincent Cavailles

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author name string

Sonia Dagnino

1

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Virginie Bellet

2

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Marina Grimaldi

3

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Anne Riu

4

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Hélène Fenet

7

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Patrick Balaguer

8

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publication date

5 January 2012

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published in

Environmental Toxicology

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volume

29

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issue

2

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page(s)

207-215

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Reporter cell lines to study the estrogenic effects of xenoestrogens

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cites work

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N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.

21 January 2018

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Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists

21 January 2018

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Synthesis of polybrominated diphenyl ethers and their capacity to induce CYP1A by the Ah receptor mediated pathway

21 January 2018

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Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin

21 January 2018

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Evaluation of an hPXR reporter gene assay for the detection of aquatic emerging pollutants: screening of chemicals and application to water samples

21 January 2018

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Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects

21 January 2018

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Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates

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Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR).

21 January 2018

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The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

21 January 2018

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Extraction and purification procedures for simultaneous quantification of phenolic xenoestrogens and steroid estrogens in river sediment by gas chromatography/ion trap mass spectrometry.

21 January 2018

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Bioanalytical characterisation of multiple endocrine- and dioxin-like activities in sediments from reference and impacted small rivers.

21 January 2018

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The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

21 January 2018

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Activation of RXR–PPAR heterodimers by organotin environmental endocrine disruptors

21 January 2018

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Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system.

21 January 2018

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Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.

21 January 2018

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The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion

21 January 2018

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Endocrine disruptors induce cytochrome P450 by affecting transcriptional regulation via pregnane X receptor

21 January 2018

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Estrogens and antiestrogens activate hPXR.

21 January 2018

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Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response.

21 January 2018

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Steroid receptor profiling of vinclozolin and its primary metabolites.

21 January 2018

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The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators

21 January 2018

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Relevant approach to assess performances of wastewater biosolids composting in terms of micropollutants removal

21 January 2018

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Binding of estrogenic compounds to recombinant estrogen receptor-alpha: application to environmental analysis

21 January 2018

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Peroxisome Proliferator-Activated Receptor γ Is a Target for Halogenated Analogs of Bisphenol A

21 January 2018

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Characterization of novel ligands of ERα, Erβ, and PPARγ: the case of halogenated bisphenol A and their conjugated metabolites

21 January 2018

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Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).

21 January 2018

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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

21 January 2018

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A novel cell line, MDA-kb2, that stably expresses an androgen- and glucocorticoid-responsive reporter for the detection of hormone receptor agonists and antagonists

21 January 2018

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Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/TOX.20787

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19 January 2020

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