Glucocorticoid receptor antagonist sensitizes TRAIL-induced apoptosis in renal carcinoma cells through up-regulation of DR5 and down-regulation of c-FLIP(L) and Bcl-2. (Q39456327)

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English	Glucocorticoid receptor antagonist sensitizes TRAIL-induced apoptosis in renal carcinoma cells through up-regulation of DR5 and down-regulation of c-FLIP(L) and Bcl-2.	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

Glucocorticoid receptor antagonist sensitizes TRAIL-induced apoptosis in renal carcinoma cells through up-regulation of DR5 and down-regulation of c-FLIP(L) and Bcl-2. (English)

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

apoptotic process

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renal carcinoma

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based on heuristic

inferred from title

author name string

Kyoung-Jin Min

1

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

Ji Hoon Jang

2

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Europe PubMed Central

PubMed publication ID

12 September 2017

Jung Tae Lee

3

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

Kyeong Sook Choi

4

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

Taeg Kyu Kwon

5

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Europe PubMed Central

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12 September 2017

publication date

19 October 2011

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Europe PubMed Central

PubMed publication ID

12 September 2017

Journal of Molecular Medicine

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Europe PubMed Central

PubMed publication ID

12 September 2017

90

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Europe PubMed Central

PubMed publication ID

12 September 2017

3

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Europe PubMed Central

PubMed publication ID

12 September 2017

309-319

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Europe PubMed Central

PubMed publication ID

12 September 2017

https://scigraph.springernature.com/pub.10.1007/s00109-011-0821-8

0 references

Mifepristone: clinical pharmacology

1 reference

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Mifepristone: antineoplastic studies

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RU486 increases radiosensitivity and restores apoptosis through modulation of HPV E6/E7 in dexamethasone-treated cervical carcinoma cells

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The antiprogestatin drug RU 486 potentiates doxorubicin cytotoxicity in multidrug resistant cells through inhibition of P-glycoprotein function.

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Identification and characterization of a new member of the TNF family that induces apoptosis

1 reference

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21 January 2018

The caspase-8 modulator c-FLIP.

1 reference

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21 January 2018

Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy

1 reference

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21 January 2018

Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis.

1 reference

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Didox (a novel ribonucleotide reductase inhibitor) overcomes Bcl-2 mediated radiation resistance in prostate cancer cell line PC-3.

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Synergy is achieved by complementation with Apo2L/TRAIL and actinomycin D in Apo2L/TRAIL-mediated apoptosis of prostate cancer cells: role of XIAP in resistance

1 reference

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21 January 2018

TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5.

1 reference

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The differential sensitivity of Bc1-2-overexpressing human breast tumor cells to TRAIL or doxorubicin-induced apoptosis is dependent on Bc1-2 protein levels.

1 reference

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21 January 2018

The receptor for the cytotoxic ligand TRAIL

1 reference

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21 January 2018

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

1 reference

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21 January 2018

CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells

1 reference

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21 January 2018

Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein

1 reference

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21 January 2018

Dexamethasone inhibits TRAIL-induced apoptosis of thyroid cancer cells via Bcl-xL induction.

1 reference

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21 January 2018

Mifepristone (RU486): a review

1 reference

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21 January 2018

Mifepristone (RU 486): current knowledge and future prospects

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0821-8

21 January 2018

Atypical induction of the unfolded protein response by mifepristone

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0821-8

21 January 2018

The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP.

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0821-8

21 January 2018

NF-kappaB balances vascular regression and angiogenesis via chromatin remodeling and NFAT displacement

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0821-8

21 January 2018

NF-kappaB signals induce the expression of c-FLIP.

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0821-8

21 January 2018

c-Fos as a proapoptotic agent in TRAIL-induced apoptosis in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS00109-011-0821-8

21 January 2018

Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells

1 reference

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21 January 2018

PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability

1 reference

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21 January 2018

Effects of progesterone and anti-progestin (mifepristone) treatment on proliferation and apoptosis of the human ovarian cancer cell line, OVCAR-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22008998

12 December 2020

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inferred from PubMed ID database lookup

Se-methylselenocysteine sensitized TRAIL-mediated apoptosis via down-regulation of Bcl-2 expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22008998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Mifepristone (RU 486)]

1 reference

https://pubmed.ncbi.nlm.nih.gov/22008998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal effect of mifepristone on adriamycin resistance in human breast cancer cell line MCF-7/ADM in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22008998

12 December 2020

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inferred from PubMed ID database lookup

Doxorubicin pretreatment sensitizes prostate cancer cell lines to TRAIL induced apoptosis which correlates with the loss of c-FLIP expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/22008998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful mifepristone treatment of recurrent, inoperable meningioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22008998

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based on heuristic

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Effect of the antiprogesterone RU-38486 on meningioma implanted into nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22008998

12 December 2020

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inferred from PubMed ID database lookup

The effects of an antiprogesterone steroid in women: interruption of the menstrual cycle and of early pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22008998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mifepristone pretreatment overcomes resistance of prostate cancer cells to tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22008998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RU486, a progestin and glucocorticoid antagonist, inhibits the growth of breast cancer cells via the progesterone receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22008998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor-related apoptosis-inducing ligand retains its apoptosis-inducing capacity on Bcl-2- or Bcl-xL-overexpressing chemotherapy-resistant tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22008998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of human ovarian carcinoma cell lines to antiprogestin mifepristone

1 reference

https://pubmed.ncbi.nlm.nih.gov/22008998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of glucocorticosteroid action in cultured L-929 mouse fibroblasts by RU 486, a new anti-glucocorticosteroid of high affinity for the glucocorticosteroid receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22008998

12 December 2020

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inferred from PubMed ID database lookup

[Induction of apoptosis by mifepristone in androgen-independent prostate cancer cell lines in vitro]

1 reference

https://pubmed.ncbi.nlm.nih.gov/22008998

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inferred from PubMed ID database lookup

Cisplatin cytotoxicity is increased by mifepristone in cervical carcinoma: an in vitro and in vivo study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22008998

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RU 38486: a potent antiglucocorticoid in vitro and in vivo

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00109-011-0821-8

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

release_qvqexc2vsjam5ftsqhtyr332eq

1 reference

https://api.fatcat.wiki/v0/release/qvqexc2vsjam5ftsqhtyr332eq

24 November 2022

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mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

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