Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease (Q39460847)

12 September 2017

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease (English)

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12 September 2017

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Valentina Di Liberto

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Petteri Piepponen

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Petteri Piepponen

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Natale Belluardo

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object named as

Natale Belluardo

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12 September 2017

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Giuseppa Mudò

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12 September 2017

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Dan Lindholm

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Laura Korhonen

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12 September 2017

Johanna Mäkelä

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12 September 2017

Timofey V Tselykh

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12 September 2017

Melania Olivieri

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Ove Eriksson

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12 September 2017

Annika Mälkiä

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12 September 2017

Alessandra Bonomo

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12 September 2017

Minna Kairisalo

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12 September 2017

Jose A Aguirre

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12 September 2017

language of work or name

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8 October 2011

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Cellular and Molecular Life Sciences

12 September 2017

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12 September 2017

69

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12 September 2017

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1153-1165

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https://scigraph.springernature.com/pub.10.1007/s00018-011-0850-z

12 September 2017

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Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance

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Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

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Transcriptional targets of sirtuins in the coordination of mammalian physiology

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PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload

21 January 2018

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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

21 January 2018

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Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways

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Resveratrol: one molecule, many targets

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Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults.

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Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity

21 January 2018

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Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice

21 January 2018

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Overexpression of growth-associated proteins in the neurons of adult transgenic mice

21 January 2018

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Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia.

21 January 2018

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The novel cyclooxygenase-2 inhibitor GW637185X protects against l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

21 January 2018

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The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.

21 January 2018

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In heterozygous GDNF knockout mice the response of striatal dopaminergic system to acute morphine is altered

21 January 2018

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Rapid suppression of mitochondrial permeability transition by methylglyoxal. Role of reversible arginine modification.

21 January 2018

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Regulation of X-chromosome-linked inhibitor of apoptosis protein in kainic acid-induced neuronal death in the rat hippocampus

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Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain

21 January 2018

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NF-kappaB-dependent regulation of brain-derived neurotrophic factor in hippocampal neurons by X-linked inhibitor of apoptosis protein

21 January 2018

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Downregulation of NF-kappaB signaling by mutant huntingtin proteins induces oxidative stress and cell death

21 January 2018

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X-linked inhibitor of apoptosis protein increases mitochondrial antioxidants through NF-kappaB activation

21 January 2018

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21 January 2018

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Effects of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine on neostriatal dopamine in mice.

21 January 2018

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X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia

21 January 2018

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XIAP decreases caspase-12 cleavage and calpain activity in spinal cord of ALS transgenic mice.

21 January 2018

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X chromosome-linked inhibitor of apoptosis protein reduces oxidative stress after cerebral irradiation or hypoxia-ischemia through up-regulation of mitochondrial antioxidants

21 January 2018

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PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons

21 January 2018

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Localization of the transcriptional coactivator PGC-1alpha to GABAergic neurons during maturation of the rat brain

21 January 2018

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Resveratrol reduces oxidative stress and cell death and increases mitochondrial antioxidants and XIAP in PC6.3-cells

21 January 2018

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Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

21 January 2018

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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

21 January 2018

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Resveratrol stimulates AMP kinase activity in neurons

21 January 2018

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Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway

21 January 2018

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Neuroprotection by resveratrol against traumatic brain injury in rats

21 January 2018

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Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease.

21 January 2018

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PPAR-gamma-mediated neuroprotection in a chronic mouse model of Parkinson's disease

21 January 2018

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PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease

21 January 2018

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Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21984601

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21984601

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

What causes cell death in Parkinson's disease?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21984601

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00018-011-0850-Z

1 reference

12 September 2017

1 reference