A role for TNFα in intervertebral disc degeneration: a non-recoverable catabolic shift. (Q39461994)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23438440%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

A role for TNFα in intervertebral disc degeneration: a non-recoverable catabolic shift (English)

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24 February 2020

6

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24 February 2020

author name string

D Purmessur

1

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24 February 2020

B A Walter

2

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24 February 2020

P J Roughley

3

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24 February 2020

D M Laudier

4

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24 February 2020

A C Hecht

5

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24 February 2020

language of work or name

English

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publication date

22 February 2013

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24 February 2020

number of pages

6

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Biochemical and Biophysical Research Communications

inferred from page(s)

published in

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24 February 2020

volume

433

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24 February 2020

page(s)

151-156

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24 February 2020

issue

1

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Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling

24 February 2020

cites work

1 reference

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An organ culture system to model early degenerative changes of the intervertebral disc

12 September 2017

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TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc

12 September 2017

1 reference

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Complex loading affects intervertebral disc mechanics and biology

12 September 2017

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Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells

12 September 2017

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Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression

12 September 2017

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Cartilage and bone extracellular matrix.

12 September 2017

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Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair

12 September 2017

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Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc

12 September 2017

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Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration.

12 September 2017

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Nitric oxide enhances aggrecan degradation by aggrecanase in response to TNF-alpha but not IL-1beta treatment at a post-transcriptional level in bovine cartilage explants

12 September 2017

1 reference

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The cell biology of intervertebral disc aging and degeneration

12 September 2017

1 reference

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Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile.

12 September 2017

1 reference

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Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration

12 September 2017

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Senescence in cells of the aging and degenerating intervertebral disc: immunolocalization of senescence-associated beta-galactosidase in human and sand rat discs

12 September 2017

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Tumor necrosis factor-alpha modulates matrix production and catabolism in nucleus pulposus tissue

12 September 2017

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The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration

12 September 2017

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Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs

12 September 2017

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

12 September 2017

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A phenotypic comparison of intervertebral disc and articular cartilage cells in the rat.

12 September 2017

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Characterization of an in vitro intervertebral disc organ culture system.

14 September 2017

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The matricellular functions of small leucine-rich proteoglycans (SLRPs).

14 September 2017

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Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration

15 June 2018

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15 June 2018

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Effect of limited nutrition on in situ intervertebral disc cells under simulated-physiological loading

15 June 2018

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TGF-beta/extracellular matrix interactions in dentin matrix: a role in regulating sequestration and protection of bioactivity.

21 August 2018

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Senescence in human intervertebral discs

21 August 2018

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Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis.

21 August 2018

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21 August 2018

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Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc

21 August 2018

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12 December 2020

Effects of TNFα-antagonists on nitric oxide production in human cartilage

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12 December 2020

Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases

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12 December 2020

Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration

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12 December 2020

Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators

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12 December 2020

10.1016/J.BBRC.2013.02.034

Identifiers

DOI

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24 February 2020

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24 February 2020

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