The R467K amino acid substitution in Candida albicans sterol 14alpha-demethylase causes drug resistance through reduced affinity. (Q39472566)

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2 November 2019

title

The R467K amino acid substitution in Candida albicans sterol 14alpha-demethylase causes drug resistance through reduced affinity (English)

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2 November 2019

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3

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2 November 2019

author name string

D C Lamb

series ordinal

1

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2 November 2019

D E Kelly

series ordinal

2

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2 November 2019

S L Kelly

series ordinal

4

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2 November 2019

language of work or name

English

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publication date

1 January 2000

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Antimicrobial Agents and Chemotherapy

2 November 2019

published in

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2 November 2019

volume

44

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2 November 2019

issue

1

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2 November 2019

page(s)

63-67

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Protein measurement with the Folin phenol reagent

2 November 2019

cites work

1 reference

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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

12 September 2017

1 reference

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Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89629

A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme

12 September 2017

1 reference

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Site-directed mutageneses of rat liver cytochrome P-450d: axial ligand and heme incorporation

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89629

The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14alpha demethylase in Candida albicans

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89629

Non-standard translational events in Candida albicans mediated by an unusual seryl-tRNA with a 5'-CAG-3' (leucine) anticodon

14 September 2017

1 reference

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Molecular genetic analysis of azole antifungal mode of action

25 September 2017

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Defective sterol C5-6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals

25 September 2017

1 reference

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Defective sterol delta 5(6) desaturase as a cause of azole resistance in Ustilago maydis.

25 September 2017

1 reference

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Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta,6 alpha-diol.

17 June 2018

1 reference

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Modeling cytochrome P450 14 alpha demethylase (Candida albicans) from P450cam.

21 August 2018

1 reference

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High prevalence of antifungal resistance in Candida spp. from patients with AIDS.

21 August 2018

1 reference

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Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients

21 August 2018

1 reference

12 December 2020

Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta5,6-desaturation

1 reference

12 December 2020

The mutation T315A in Candida albicans sterol 14alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity

1 reference

12 December 2020

Molecular analysis of cyp51 from fluconazole-resistant Candida albicans strains

1 reference

12 December 2020

Purified liver microsomal NADPH-cytochrome P-450 reductase. Spectral characterization of oxidation-reduction states

1 reference

12 December 2020

Interaction of azole antifungal agents with cytochrome P-45014DM purified from Saccharomyces cerevisiae microsomes

1 reference

12 December 2020

The mechanism of the acyl-carbon bond cleavage reaction catalyzed by recombinant sterol 14 alpha-demethylase of Candida albicans (other names are: lanosterol 14 alpha-demethylase, P-45014DM, and CYP51)

1 reference

12 December 2020

10.1128/AAC.44.1.63-67.2000

Identifiers

DOI

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2 November 2019

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2 November 2019

PubMed publication ID

10602724

1 reference