An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8. (Q39473222)

12 September 2017

title

An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8. (English)

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12 September 2017

Toshiya Takahashi

1

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12 September 2017

Yutaka Kimura

2

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12 September 2017

Rumiko Saito

3

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12 September 2017

Yoshihiro Nakajima

4

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12 September 2017

Yoshihiro Ohmiya

5

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12 September 2017

Kenshi Yamasaki

6

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12 September 2017

Setsuya Aiba

7

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12 September 2017

publication date

13 September 2011

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12 September 2017

published in

Toxicological Sciences

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12 September 2017

volume

124

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12 September 2017

issue

2

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12 September 2017

page(s)

359-369

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p38 Mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene

12 September 2017

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A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-alpha, and contact sensitizers

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The cytokine-dependent MUTZ-3 cell line as an in vitro model for the screening of contact sensitizers.

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Reproducible prediction of contact allergenic potency using the local lymph node assay

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Comparison of the local lymph node assay with the guinea-pig maximization test for the detection of a range of contact allergens

21 January 2018

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Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways: role of TNF-alpha and MAPK.

21 January 2018

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Thiol antioxidants block the activation of antigen-presenting cells by contact sensitizers

21 January 2018

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Analysis of interleukin-1alpha (IL-1alpha) and interleukin-8 (IL-8) expression and release in in vitro reconstructed human epidermis for the prediction of in vivo skin irritation and/or sensitization

21 January 2018

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Modulation of phenotype, cytokine production and stimulatory function of CD34+-derived DC by NiCl(2) and SDS.

21 January 2018

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Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro.

21 January 2018

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A chemical dataset for evaluation of alternative approaches to skin-sensitization testing.

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Elucidating changes in surface marker expression of dendritic cells following chemical allergen treatment

21 January 2018

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Oxidation of cell surface thiol groups by contact sensitizers triggers the maturation of dendritic cells.

21 January 2018

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21 January 2018

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21 January 2018

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Use of IL-8 release and p38 MAPK activation in THP-1 cells to identify allergens and to assess their potency in vitro.

21 January 2018

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21 January 2018

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Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells

21 January 2018

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IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity

21 January 2018

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21 January 2018

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21 January 2018

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Simultaneous monitoring of independent gene expression patterns in two types of cocultured fibroblasts with different color-emitting luciferases

21 January 2018

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Production of IL-8 in THP-1 cells following contact allergen stimulation via mitogen-activated protein kinase activation or tumor necrosis factor-alpha production

21 January 2018

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High-resolution transcriptional profiling of chemical-stimulated dendritic cells identifies immunogenic contact allergens, but not prohaptens

21 January 2018

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Thiol redox transitions in cell signaling: a lesson from N-acetylcysteine.

21 January 2018

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Assessment of the U937 cell line for the detection of contact allergens

21 January 2018

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Regulation of interleukin-8 gene expression

21 January 2018

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Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT). II. An inter-laboratory study of the h-CLAT.

21 January 2018

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Dendritic cells: biology of the skin

21 January 2018

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CXCL8 secretion by dendritic cells predicts contact allergens from irritants

21 January 2018

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TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFR237

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12 September 2017

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