Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism. (Q39502512)

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English	Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism.	scientific article

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8 February 2020

Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism (English)

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8 February 2020

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Gábor Merényi

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8 February 2020

Júlia Kovári

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Judit Tóth

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8 February 2020

Enik Takács

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8 February 2020

Imre Zagyva

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Beáta G Vértessy

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1 June 2011

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Nucleosides, Nucleotides & Nucleic Acids

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369-390

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8 February 2020

Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2011.582849

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The role of dUTPase and uracil-DNA repair in cancer chemotherapy

1 reference

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Lethality of a dut (deoxyuridine triphosphatase) mutation in Escherichia coli

1 reference

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Thymine metabolism and thymineless death in prokaryotes and eukaryotes

1 reference

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5-Fluorouracil: mechanisms of action and clinical strategies

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5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers

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Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward?

1 reference

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21 January 2018

Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331

1 reference

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21 January 2018

Modulation of human dUTPase using small interfering RNA

1 reference

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A tyrosine kinase inhibitor, beta-hydroxyisovalerylshikonin, induced apoptosis in human lung cancer DMS114 cells through reduction of dUTP nucleotidohydrolase activity

1 reference

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Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status

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Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells

1 reference

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Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells

1 reference

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21 January 2018

5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity

1 reference

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Yeast gene CDC8 encodes thymidylate kinase and is complemented by herpes thymidine kinase gene TK

1 reference

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21 January 2018

Kinetic properties and specificity of trimeric Plasmodium falciparum and human dUTPases

1 reference

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Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme

1 reference

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21 January 2018

Flexible glycine rich motif of Escherichia coli deoxyuridine triphosphate nucleotidohydrolase is important for functional but not for structural integrity of the enzyme

1 reference

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21 January 2018

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.

1 reference

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21 January 2018

Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase

1 reference

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A new mathematical model for relative quantification in real-time RT-PCR

1 reference

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21 January 2018

dUTPase and nucleocapsid polypeptides of the Mason-Pfizer monkey virus form a fusion protein in the virion with homotrimeric organization and low catalytic efficiency

1 reference

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21 January 2018

Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase

1 reference

https://api.crossref.org/works/10.1080%2F15257770.2011.582849

21 January 2018

Developmental regulation of dUTPase in Drosophila melanogaster

1 reference

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A direct colorimetric assay for Ca2+ -stimulated ATPase activity

1 reference

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Active site of mycobacterial dUTPase: structural characteristics and a built-in sensor

1 reference

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Catalytic and structural role of the metal ion in dUTP pyrophosphatase

1 reference

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21 January 2018

Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site

1 reference

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21 January 2018

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10.1080/15257770.2011.582849

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21780905%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21780905%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

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