N-acetylcysteine modulates the cytotoxic effects of Paclitaxel (Q39502911)

12 September 2017

title

N-acetylcysteine modulates the cytotoxic effects of Paclitaxel (English)

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12 September 2017

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Patricia Anne Lyle

1

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Panagiotis Mitsopoulos

series ordinal

2

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Zacharias E Suntres

series ordinal

3

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publication date

20 July 2011

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volume

57

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issue

4

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page(s)

298-304

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Pharmacogenomics of paclitaxel

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cites work

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Pharmacology, pharmacokinetics and pharmacogenomics of paclitaxel

21 January 2018

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Signal transduction pathways of taxanes-induced apoptosis

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Paclitaxel targets mitochondria upstream of caspase activation in intact human neuroblastoma cells.

21 January 2018

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Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules

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Taxol induces caspase-10-dependent apoptosis

21 January 2018

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Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress.

21 January 2018

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Taxol induces oxidative neuronal cell death by enhancing the activity of NADPH oxidase in mouse cortical cultures

21 January 2018

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Cell signaling. H2O2, a necessary evil for cell signaling

21 January 2018

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Direct oxidative modifications of signalling proteins in mammalian cells and their effects on apoptosis.

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Reactive oxygen species, cellular redox systems, and apoptosis

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Redox regulation of cell survival

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Antioxidants in cancer therapy: is there a rationale to recommend antioxidants during cancer therapy?

21 January 2018

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Effect of Vitamin C on Lipidperoxidation and Antioxidant Status in Tamoxifen-Treated Breast Cancer Patients

21 January 2018

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Use of antioxidants during chemotherapy and radiotherapy should be avoided.

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Paradoxical roles for antioxidants in tumor prevention and eradication

21 January 2018

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Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a review

21 January 2018

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N-acetylcysteine and neurodegenerative diseases: basic and clinical pharmacology

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Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo.

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Novel action of paclitaxel against cancer cells: bystander effect mediated by reactive oxygen species

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Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells in vitro and in vivo

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Hydrogen peroxide as a cell-survival signaling molecule.

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Association of oxidative stress with realgar-induced differentiation in human leukemia HL-60 cells

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Interaction with substrate sensitises caspase-3 to inactivation by hydrogen peroxide.

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Regulation of apoptosis through cysteine oxidation: implications for fibrotic lung disease.

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Nox proteins in signal transduction

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NOX2 and NOX4 mediate proliferative response in endothelial cells.

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Should patients undergoing chemotherapy and radiotherapy be prescribed antioxidants?

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Identifiers

DOI

10.1159/000329510

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12 September 2017

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